Wnt通路在许多发育和疾病相关的过程中起着核心作用。这种细胞间信号级联在众多的有线虫类系中表现出的惊人稳定性表明它与多细胞生物共同进化以调节独特细胞类型的生成和空间排列。通过调节细胞命运规格、有丝分裂活性和细胞极性，Wnt信号调节器协调发展和组织稳态，其失调可导致发育缺陷、癌症和退行性疾病。我们评估了对这一关键途径的理解以及从Wnt蛋白生产和分泌到接收细胞的细胞质中的信号传递中的进展。我们讨论了这条路线的进化历史以及内源性和合成调节其活动的模拟器。最后，我们强调尚未解决的Wnt信号转导知识缺口和未来研究方向。

The Wnt pathway is central to a host of developmental and disease-related processes. The remarkable conservation of this intercellular signaling cascade throughout metazoan lineages indicates that it coevolved with multicellularity to regulate the generation and spatial arrangement of distinct cell types. By regulating cell fate specification, mitotic activity, and cell polarity, Wnt signaling orchestrates development and tissue homeostasis, and its dysregulation is implicated in developmental defects, cancer, and degenerative disorders. We review advances in our understanding of this key pathway, from Wnt protein production and secretion to relay of the signal in the cytoplasm of the receiving cell. We discuss the evolutionary history of this pathway as well as endogenous and synthetic modulators of its activity. Finally, we highlight remaining gaps in our knowledge of Wnt signal transduction and avenues for future research.