代谢综合征（MetS）在全球范围内日益增加，并且因其与心血管疾病、2型糖尿病和癌症的关联而在临床上具有显著意义。虽然MetS的发病机制尚未被明确阐明，但胰岛素抵抗和中心性肥胖引起的慢性低度炎症被广泛接受作为潜在的病理生理学。因此，胰岛素抵抗指数、脂肪激素和各种炎症标志物已被建议作为可靠的MetS生物标志物。其他生物标志物，如尿酸、碱性磷酸酶、γ-谷氨酰转移酶，也已知与MetS呈正相关，并且可能具有诊断用途。在本综述中，我们提供了MetS生物标志物的全面概述，并开发了系统化实验室分析方法。版权所有©2022 Elsevier Inc.。

Metabolic syndrome (MetS) is increasing globally and is clinically significant due to its association with cardiovascular disease, type 2 diabetes and cancer. Although the pathogenesis of MetS has not been clearly elucidated, insulin resistance and chronic low-grade inflammation derived from central obesity are the most widely accepted as underlying pathophysiology. Accordingly, insulin resistance indices, adipokines and various inflammatory markers have been suggested as reliable biomarkers for MetS. Others, such as uric acid, alkaline phosphatase, γ-glutamyl transferase, are also known to positively correlate with MetS and could be diagnostically useful. In this review, we provide a comprehensive overview of MetS biomarkers and the development of a systematic approach to laboratory analysis.Copyright © 2022 Elsevier Inc. All rights reserved.