代谢综合征的新标记
New markers in metabolic syndrome
影响因子:6.30300
发表日期:2022
作者:
Da-Hye Son, Hyun-Su Ha, Hye-Min Park, Hae-Young Kim, Yong-Jae Lee
摘要
代谢综合征（METS）在全球增加，并且由于其与心血管疾病，2型糖尿病和癌症的关系而具有临床意义。尽管尚未清楚地阐明MetS的发病机理，但胰岛素抵抗和慢性低度炎症是从中央肥胖而产生的，是最广泛地接受为潜在的病理生理学。因此，胰岛素抵抗指数，脂肪因子和各种炎症标记被认为是Mets的可靠生物标志物。其他的，例如尿酸，碱性磷酸酶，γ-谷氨酰转移酶，也已知与MetS正相关，并且可以在诊断上有用。在这篇综述中，我们提供了Mets生物标志物的全面概述以及一种系统的实验室分析方法。
Abstract
Metabolic syndrome (MetS) is increasing globally and is clinically significant due to its association with cardiovascular disease, type 2 diabetes and cancer. Although the pathogenesis of MetS has not been clearly elucidated, insulin resistance and chronic low-grade inflammation derived from central obesity are the most widely accepted as underlying pathophysiology. Accordingly, insulin resistance indices, adipokines and various inflammatory markers have been suggested as reliable biomarkers for MetS. Others, such as uric acid, alkaline phosphatase, γ-glutamyl transferase, are also known to positively correlate with MetS and could be diagnostically useful. In this review, we provide a comprehensive overview of MetS biomarkers and the development of a systematic approach to laboratory analysis.