目前，纳米技术领域的新进展在医学领域开辟了新的前景，可能为我们提供解决许多医疗并发症的方案。虽然有多种纳米粒子正在探索作为纳米药物使用，但由于其生物相容性和其可切换的氧化态（+3和+4），或者说具有根据pH条件作为促氧化剂和抗氧化剂的能力，氧化铈纳米颗粒（CeO2 NPs）是最具吸引力的。绿色合成纳米颗粒更受青睐，可使其更经济、环保、毒性较小。我们研究的目的是利用诺丽（Noni）叶提取物制备CeO2 NPs，并研究其在光学、结构、抗菌和抗癌能力方面的表现。采用X射线衍射（XRD）、透射电子显微镜（TEM）、能谱分析（EDAX）、傅里叶变换红外光谱（FTIR）、紫外可见光谱（UV-vis）和光致发光测量方法完成了CeO2 NPs的光学和结构特征分析。与阿莫西林相比，我们的CeO2 NPs对革兰氏阳性S. aureus和S. pneumonia以及革兰氏阴性E. coli和K. pneumonia都表现出强烈的抗菌作用。进一步研究了绿色合成的CeO2 NPs对人类急性淋巴细胞白血病（ALL）MOLT-4细胞的抗癌特性，通过细致研究其减少癌细胞活力（细胞毒性）、促进细胞凋亡、增加细胞内反应性氧化物种（ROS）积累、降低线粒体膜电位（MMP）水平、改变细胞黏附以及增加前凋亡标记物caspase-3、-8和-9在肿瘤细胞中的激活，结果表明我们绿色合成的CeO2 NPs是一种优秀的癌症替代治疗候选方案。 Copyright©2022 Abozer Y. Elderdery等

Currently, new advancements in the area of nanotechnology opened up new prospects in the field of medicine that could provide us with a solution for numerous medical complications. Although a several varieties of nanoparticles is being explored to be used as nanomedicines, cerium oxide nanoparticles (CeO2 NPs) are the most attractive due to their biocompatibility and their switchable oxidation state (+3 and +4) or in other words the ability to act as prooxidant and antioxidant depending on the pH condition. Green synthesis of nanoparticles is preferred to make it more economical, eco-friendly, and less toxic. The aim of our study here is to formulate the CeO2 NPs (CeO2 NPs) using Morinda citrifolia (Noni) leaf extract and study its optical, structural, antibacterial, and anticancer abilities. Their optical and structural characterization was accomplished by employing X-ray diffractography (XRD), TEM, EDAX, FTIR, UV-vis, and photoluminescence assays. Our CeO2 NPs expressed strong antibacterial effects against Gram-positive S. aureus and S. pneumonia in addition to Gram-negative E. coli and K. pneumonia when compared with amoxicillin. The anticancer properties of the green synthesized CeO2 NPs against human acute lymphoblastic leukemia (ALL) MOLT-4 cells were further explored by the meticulous study of their ability to diminish cancer cell viability (cytotoxicity), accelerate apoptosis, escalate intracellular reactive oxygen species (ROS) accumulation, decline the mitochondria membrane potential (MMP) level, modify the cell adhesion, and shoot up the activation of proapoptotic markers, caspase-3, -8, and -9, in the tumor cells. Altogether, the outcomes demonstrated that our green synthesized CeO2 NPs are an excellent candidate for alternative cancer therapy.Copyright © 2022 Abozer Y. Elderdery et al.