全球肥胖症和2型糖尿病的患病率已经达到了流行病的状态，在社会上造成了沉重的负担。因此，寻找能用于潜在治疗策略的新机制和靶点至关重要。因此，细胞内膜转运已经重新出现作为控制代谢稳态的调节工具。膜转运是一种重要的生理过程，负责不同细胞器和质膜之间的信号受体、膜转运体、激素或其他配体的分类和分配。细胞内转运的失调与很多人类疾病有关，包括癌症、神经退行性疾病、免疫缺陷和代谢性疾病，如2型糖尿病及其相关并发症。本文重点介绍内体膜转运在体内代谢生理和病理方面的最新进展，强调这一研究领域在靶向代谢性疾病方面的重要性。© 2022. Springer Nature Limited.

The global prevalences of obesity and type 2 diabetes mellitus have reached epidemic status, presenting a heavy burden on society. It is therefore essential to find novel mechanisms and targets that could be utilized in potential treatment strategies and, as such, intracellular membrane trafficking has re-emerged as a regulatory tool for controlling metabolic homeostasis. Membrane trafficking is an essential physiological process that is responsible for the sorting and distribution of signalling receptors, membrane transporters and hormones or other ligands between different intracellular compartments and the plasma membrane. Dysregulation of intracellular transport is associated with many human diseases, including cancer, neurodegeneration, immune deficiencies and metabolic diseases, such as type 2 diabetes mellitus and its associated complications. This Review focuses on the latest advances on the role of endosomal membrane trafficking in metabolic physiology and pathology in vivo, highlighting the importance of this research field in targeting metabolic diseases.© 2022. Springer Nature Limited.