风险分层和收治于医院急救小组重症监护病房的患者的长期预后:奥地利最大的医疗中心的经验。
Risk stratification and long-term outcome of patients receiving in-hospital medical emergency team critical care: experience from Austria's largest medical center.
发表日期:2022 Oct 18
作者:
Safoura Sheikh Rezaei, Constantin Gatterer, Patrick Sulzgruber, Felix Hofer, Helene Mittlboeck, Stefan Gavrilovic, Yannick Loyoddin, Michael Wolzt, Robert Schönbauer, Walter Speidl, Bernhard Richter, Gottfried Heinz, Michael Sponder
来源:
MINERVA MEDICA
摘要:
我们旨在研究有或没有院内心脏停跳 (IHCA) 的医疗急救小组 (MET) 会诊住院患者长期生存的预测因素,该研究在奥地利最大的医疗中心回顾性分析了在 2014 年 1 月至 2020 年 3 月期间需要 MET 干预的患者数据。总共分析了 708 次 MET 呼叫。最短随访时间为 7 个月,最长为 6.2 年。主要的 MET 指征是循环衰竭 (63%),其次是呼吸衰竭 (27.1%) 和出血事件 (3.5%)。425 (60%) 患者经历了 IHCA 及随后的心肺复苏术 (CPR)。其中,274 (64%) 患者恢复自主循环 (ROSC),221 (52%) 存活了前 24 小时 (中位生存期:146 天),22.1% 存活了第一年。在调整潜在混杂因素后,年龄 (p<0.001)、ROSC 时间 (p<0.001)、非可电击性心律失常 (p=0.041)、慢性肾脏疾病 (CKD, p=0.041)、峰值乳酸水平 (p<0.001) 和 C-反应蛋白 (p=0.001) 与 IHCA 患者长期全因死亡率相关。 被减少到 IHCA 之外的原因的 283 次 MET 呼叫 (40%) 与更好的 24 小时 (93%) 和一年存活率 (61.8%) 相关。除年龄 (p<0.001) 外,MET 患者未出现 IHCA 与死亡率相关的主要危险因素包括合并疾病,如慢性阻塞性肺部疾病 (COPD, p=0.008)、CKD (p=0.001)、肺动脉高压/慢性血栓性肺动脉高压 (PH/CTEPH, p=0.024) 和癌症 (p=0.040)。触发 MET 呼叫的患者有更高的死亡率,特别是那些有 IHCA 的患者。死亡率的预测因素包括年龄、合并疾病和与心脏骤停相关的参数。更好地表征 MET 呼叫人群及其结果可能有助于改进临床决策。
We aimed to investigate predictors for long-term survival of in-hospital patients with medical emergency team (MET) consultation with or without in-hospital cardiac arrest (IHCA) in Austria's largest medical center.Data of patients, who needed an intervention of a MET between 01/2014 and 03/2020 were reviewed for this retrospective analysis.In total, 708 MET calls were analyzed. The minimum follow-up was 7 months, the maximum 6.2 years. The main MET indications were circulatory failure (63%) followed by respiratory failure (27.1%), and bleeding events (3.5%). IHCA with subsequent cardiopulmonary resuscitation (CPR) was experienced by 425 (60%) patients. Of those, 274 (64%) reached return of spontaneous circulation (ROSC), and 221 (52%) survived the first 24-hours (median survival: 146 days) and 22.1% the first year. After adjustment for potential confounders, age (p<0.001), time to ROSC (p<0.001), a non-shockable rhythm (p=0.041), chronic kidney disease (CKD, p=0.041), peak lactate levels (p<0.001), and C-reactive protein (p=0.001) were associated with long-term all-cause mortality in IHCA patients in Cox regression analysis. The 283 MET calls (40%) which were due to other reasons than IHCA were associated with a much better 24-hours (93%) and 1-year survival (61.8%). Beside age (p<0.001), the main risk factors associated with mortality in MET patients without IHCA were comorbidities such as chronic obstructive pulmonary disease (COPD, p=0.008), CKD (p=0.001), pulmonary hypertension/chronic thromboembolic pulmonary hypertension (PH/CTEPH, p=0.024), and cancer (p=0.040).Patients triggering MET calls have an increased mortality, especially those with IHCA. Predictors of mortality comprise age, comorbidities, and cardiac arrest-related parameters. A better characterization of MET call populations and their outcome might help to improve clinical decision making.