成人炎症指标与骨代谢的关系已广为人知，有研究显示有氧运动能力（CRF）与炎症指标呈负相关。因此，我们测试了代谢综合征成人中CRF与骨代谢标志物之间是否由炎症指标调节的关联。分析共纳入81名成人（年龄58.5±5.0岁，62.7%为女性）。CRF通过6分钟步行测试进行测量。采用敏感ELISA试剂盒评估血清白细胞介素（IL）-1β、IL-6、IL-10、肿瘤坏死因子α、高敏感C-反应蛋白（hsCRP），以及血管内皮生长因子、胶原类型I交联C-端肽、原胶原I N-端前肽（P1NP）和总骨钙素指标。采用双能X射线吸收法评估体成分。采用偏相关分析，控制性别、瘦体重和脂肪重，测试CRF、炎症指标和骨代谢指标之间的关系。进行Bootstrap样本的中介过程，间接效应的置信区间不包括零则为具有统计学意义。发现CRF与P1NP水平呈正相关（r=.228，p=.044）和osteocalcin水平呈正相关（r=.296，p=.009）；此外，CRF与IL-1β水平呈正相关（r=.340，p=.002），与hsCRP水平呈负相关（r=-.335，p=.003），而IL-1β水平与P1NP水平呈正相关（r=.245，p=.030），hsCRP水平与P1NP水平呈负相关（r=-.319，p=.004）；最后，CRF与P1NP水平之间的关联完全由hsCRP中介（中介效应百分比为39.9）。因此，此人群中CRF对骨形成的益处可能取决于hsCRP浓度。

The relationship between inflammatory markers and bone turnover in adults is well known, and a negative association between cardiorespiratory fitness (CRF) and inflammatory markers has also been described. Hence, we tested whether the association between CRF and bone turnover markers is mediated by inflammatory markers in adults with metabolic syndrome. A total of 81 adults (58.5 ± 5.0 years, 62.7% women) were included in the analysis. CRF was measured by the 6-min walking test. Serum interleukin (IL)-1β, IL-6, IL-10, tumor necrosis factor alpha, high-sensitivity c-reactive protein (hsCRP) and vascular endothelial growth factor, collagen type I cross-linked C-telopeptide, procollagen type I N-terminal propeptide (P1NP), and total osteocalcin were assessed using a sensitive ELISA kit. Body composition was assessed by dual-energy X-ray absorptiometry. Partial correlation was used to test the relationship between CRF, inflammatory markers, and bone turnover markers, controlling for sex, lean mass, and fat mass. Boot-strapped mediation procedures were performed, and indirect effects with confidence intervals not including zero were interpreted as statistically significant. CRF was positively correlated with P1NP levels (r = .228, p = .044) and osteocalcin levels (r = .296, p = .009). Furthermore, CRF was positively correlated with IL-1β levels (r = .340, p = .002) and negatively correlated with hsCRP levels (r = -.335, p = .003), whereas IL-1β levels were positively correlated with P1NP levels (r = .245, p = .030), and hsCRP levels were negatively correlated with P1NP levels (r = -.319, p = .004). Finally, the association between CRF and P1NP levels was totally mediated by hsCRP (percentage of mediation = 39.9). Therefore, CRF benefits on bone formation could be dependent on hsCRP concentrations in this population.