在豚鼠实验中，评估将自生物降解支架插入幽门来预防幽门保存性胃切除术后延迟胃排空是否可行和安全。自生物降解哑铃形幽门支架由可吸收缝合材料设计而成：聚乙二醇-羟基己酸酯-己内酯（PGCL）或聚-p-二噁烷酮（PPDO）。在十头猪的胃切开术后，每个支架被插入：两个假手术组，四个PGCL 支架和四个PPDO 支架。评估体重（Bwt）、体温（BT）、全血细胞计数（CBC）和普通X射线。在术后第13天，进行组织学评估安乐死。所有十头猪中的手术都成功进行。不加标记的缝合，两个支架在第3天之前就移位了。移位延迟到了第13天，当标记缝合物（-t）被加在支架和胃壁之间时。PGCL 的自降解从第3天开始，支架在第8天以前从腹部完全排出。虽然PPDO 也在自降解过程中变得更加脆弱，但其形状在胃肠道内维持了13天。出现PPDO-t2头猪 在第10天突然死亡，这更可能是急性肠扭转而非支架相关并发症导致的。以Bwt、BT、CBC和组织学为指标，三组之间没有显著差异（假手术组 vs. PGCL 组 vs. PPDO 组，所有p > 0.05）。利用吸收缝合材料制成生物可降解支架的概念，在豚鼠实验中似乎是可行的。其中，快速吸收的PGCL似乎在考虑安全性的方面更适合于暂时的幽门可吸收支架。©2022年。作者独家许可给国际胃癌协会和日本胃癌协会。

To evaluate whether insertion of self-biodegradable stent into the pylorus to prevent delayed-gastric emptying after pylorus-preserving gastrectomy is feasible and safe through porcine experiment.Self-biodegradable dumbbell-shaped pyloric stents were designed from absorbable suture materials: poly(glycolide-co-caprolactone) (PGCL) or poly-p-dioxanone (PPDO). After gastrotomy on ten pigs, each stent was inserted: two shams, four PGCL stents, and four PPDO stents. Body weight (Bwt), body temperature (BT), complete blood cell (CBC) count, and plain X-ray were evaluated. On postoperative day (POD) 13, euthanasia was performed for histologic evaluation.Operation was successfully performed in all ten pigs. Without tagging suture, both stents migrated before POD 3. The migration was delayed up to POD 13, when the tagging sutures (-t) were applied between stent and stomach wall. Self-degradation of PGCL started from POD 3, and stents were completely excreted from the abdomen by POD 8. Although PPDO were also weakened as self-degradation progressed, its shape was maintained in gastrointestinal tract for 13 days. Unexpected sudden death occurred in the pig with PPDO-t2 on POD 10, which is more likely due to acute volvulus rather than stent-related complication. There was no significant difference between three groups in terms of Bwt, BT, CBC, and histology (sham vs. PGCL vs. PPDO, all p > 0.05).The concept of biodegradable stents made of absorbent suture material seems feasible in porcine experiment. Among them, PGCL which has shown rapid absorption, appears to be a more suitable material for transient pyloric absorbable stent when considering safety aspect.© 2022. The Author(s) under exclusive licence to The International Gastric Cancer Association and The Japanese Gastric Cancer Association.