RNA结合蛋白39的生物功能及多样化调控的洞察以及它们在人类疾病中的意义。
Insights on the biological functions and diverse regulation of RNA-binding protein 39 and their implication in human diseases.
发表日期：2023 Mar
作者：
Morgane Eléouët, Chengpiao Lu, Yijia Zhou, Ping Yang, Jingjing Ma, Guoqiang Xu
来源：
Bba-Gene Regul Mech
摘要：
RNA结合蛋白39(RBM39)参与了前mRNA剪接和转录调控。在许多癌症中，RBM39功能失调，并且其上调增强了癌细胞的增殖。最近，有研究发现芳基磺酰胺可作为分子胶来招募RBM39至CRL4DCAF15 E3泛素连接酶复合物以进行泛素化和蛋白酶解。因此，各种研究聚焦于通过芳基磺酰胺降解RBM39，以寻找新的癌症治疗方法。这些发现也引起了人们对RBM39生物功能的深入研究。研究发现，RBM39主要调节参与前mRNA剪接、细胞周期调控、DNA损伤应答和代谢的基因的剪接和转录，但对这些调控的了解还处于起步阶段。本文回顾了当前文献的进展并讨论了RBM39在翻译后水平的生物功能和动态调控的关键问题。版权所有©2022 Elsevier B.V.发布。
RNA-binding protein 39 (RBM39) involves in pre-mRNA splicing and transcriptional regulation. RBM39 is dysregulated in many cancers and its upregulation enhances cancer cell proliferation. Recently, it has been discovered that aryl sulfonamides act as molecular glues to recruit RBM39 to the CRL4DCAF15 E3 ubiquitin ligase complex for its ubiquitination and proteasomal degradation. Therefore, various studies have focused on the degradation of RBM39 by aryl sulfonamides in the aim of finding new cancer therapeutics. These discoveries also attracted focus for thorough study on the biological functions of RBM39. RBM39 was found to regulate the splicing and transcription of genes mainly involved in pre-mRNA splicing, cell cycle regulation, DNA damage response, and metabolism, but the understanding of these regulations is still in its infancy. This article reviews the advances of the current literature and discusses the remaining key issues on the biological function and dynamic regulation of RBM39 at the post-translational level.Copyright © 2022. Published by Elsevier B.V.