癌干细胞（CSC）是肿瘤的一种亚群，与转移和复发有关。目前的化疗药物选项在其管理剂量下对CSC无效。需要新的细胞毒素类别和新的高度特异性的递送方式来提供持久的临床效果。近年来，无机化合物作为一种有临床相关效能的抗CSC剂类别更是呈现了良好的前景。在本篇简短的评论中，我们介绍了针对抗CSC金属配合物的最新进展（2020年之后）。这些金属配合物在单层和三维的CSC培养和动物模型中的活性受到了记录。我们还强调了这些金属配合物在化学结构方面的机制。 版权所有 © 2022 作者。由Elsevier Ltd.出版。保留所有权利。

Cancer stem cells (CSC) are a sub-population of tumours linked to metastasis and relapse. Current chemotherapeutic drug options are ineffective against CSCs at their administered doses. New families of cytotoxic agents, and new, highly specific ways of delivering them to CSCs, are needed to provide durable clinical outcomes. Inorganic compounds have recently emerged as a promising class of anti-CSC agents with clinically relevant potencies. In this short review, we present the very latest efforts (post-2020) on the development of anti-CSC metal complexes. The activities of the metal complexes in monolayer and three-dimensional CSC cultures and animal models is documented. The mechanism of action of the metal complexes with respect to their chemical structures is also highlighted.Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.