该综述目的在于确定针对过敏和免疫紊乱的临床前和临床研究，评估迷迭香酸（RA）、山葵酸（CaA）、玫瑰酚（RO）、迷迭香酚（CA）和熊果酸（UA）的作用。从创建至2022年10月，通过多个在线数据库，包括PubMed、Science Direct、EMBASE、Web of Sciences、Cochrane trials和Scopus进行检索。由于核因子-κB（NF-κB）通路的抑制，在过敏性哮喘的主要因素中，RA可能成为哮喘治疗的有希望的候选药物。包括CA和UA的其他成分具有减少白细胞介素（IL）-4、IL-5和IL-13表达以及改善气道炎症的作用。迷迭香的抗癌作用通过多种机制介导，包括DNA裂解、诱导细胞凋亡、抑制星形胶质细胞上调基因-1表达以及阻碍细胞在G1期的周期进程。这些化合物本质上找到于迷迭香精油中，其通过钙拮抗作用阻止平滑肌收缩，抑制乙酰胆碱（ACH）、组织胺和去甲肾上腺素的刺激。此外，CA表现出与一类轻松平滑肌的药物相比，更大的与膜上乙酰胆碱（ACH）受体的相互作用，从而成为潜在的解痉治疗。这些组分已经在免疫、过敏和呼吸系统疾病中展示出治疗效果。©2022年国际生物化学和分子生物学联合会。

This review aimed to identify preclinical and clinical studies examining the effects of rosmarinic acid (RA), carnosic acid (CaA), rosmanol (RO), carnosol (CA), and ursolic acid (UA) against allergic and immunologic disorders. Various online databases, including PubMed, Science Direct, EMBASE, Web of Sciences, Cochrane trials, and Scopus, were searched from inception until October 2022. Due to the suppression of the nuclear factor-κB (NF-κB) pathway, the main factor in allergic asthma, RA may be a promising candidate for the treatment of asthma. The other ingredients comprising CA and UA reduce the expression of interleukin (IL)-4, IL-5, and IL-13 and improve airway inflammation. Rosemary's anti-cancer effect is mediated by several mechanisms, including DNA fragmentation, apoptosis induction, inhibition of astrocyte-upregulated gene-1 expression, and obstruction of cell cycle progression in the G1 phase. The compounds, essentially found in Rosemary essential oil, prevent smooth muscle contraction through its calcium antagonistic effects, inhibiting acetylcholine (ACH), histamine, and norepinephrine stimulation. Additionally, CA exhibits a substantially greater interaction with the nicotinic ACH receptor than a family of medications that relax the smooth muscles, making it a potent antispasmodic treatment. The components have demonstrated therapeutic effects on the immune, allergy, and respiratory disorders.© 2022 International Union of Biochemistry and Molecular Biology.