实体肿瘤拥有独特的肿瘤微环境（TME），其中包括缺氧、低酸度、高过氧化氢和谷胱甘肽（GSH）水平等等。这些独特的因素为肿瘤的发展和扩散提供了有利的微环境和营养，同时也作为特定和成功的癌症治疗的通道。一个很好的例子是金属过氧化物结构，它们已被合成并用于增强氧供应，已经显示出在缓解缺氧方面有着极大的潜力。在缺氧环境下，某些依赖氧气的治疗，如光动力疗法和放射疗法，会失败，因此调节缺氧的肿瘤微环境已被发现可以增强某些药物的抗肿瘤影响。在酸性环境下，金属过氧化物与水反应所产生的过氧化氢不仅诱导氧化应激，还产生额外的氧气。这是因为过氧化氢作为催化酶等分子的反应亚基，减轻了观察到的肿瘤微环境中的缺氧。在这个过程中释放的金属离子也可以提供自己独特的生物活性。用于抗癌治疗的金属过氧化物是一个快速发展的领域，有很好的证据表明它们是调节肿瘤微环境的一个好选择。在这方面，还强调了针对肿瘤微环境的金属过氧化物成功应用的合成和机制。此外，本文还讨论了TME的各种特征，如血管生成、炎症、缺氧、酸度水平和金属离子平衡，以及某些形式的协同组合治疗。 版权所有©2022Simon Ngigi Mbugua。

Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen-dependent treatments such as photodynamic therapy and radiotherapy fail to respond and therefore modulating the hypoxic tumor microenvironment has been found to enhance the antitumor impact of certain drugs. Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxides with water not only induces oxidative stress but also produces additional oxygen. This is achieved since hydrogen peroxide acts as a reactive substrate for molecules such as catalyse enzymes, alleviating tumor hypoxia observed in the tumor microenvironment. Metal ions released in the process can also offer distinct bioactivity in their own right. Metal peroxides used in anticancer therapy are a rapidly evolving field, and there is good evidence that they are a good option for regulating the tumor microenvironment in cancer therapy. In this regard, the synthesis and mechanisms behind the successful application of metal peroxides to specifically target the tumor microenvironment are highlighted in this review. Various characteristics of TME such as angiogenesis, inflammation, hypoxia, acidity levels, and metal ion homeostasis are addressed in this regard, together with certain forms of synergistic combination treatments.Copyright © 2022 Simon Ngigi Mbugua.