恶性胶质瘤（GBM）是胶质瘤中最恶性的形式，也是成人最常见和致命的原发性脑肿瘤。传统的癌症治疗对GBM效果有限。GBM细胞响应并适应周围被称为肿瘤微环境（TME）的脑实质来促进肿瘤保存。在特定的TME中，有三种特别令人感兴趣的GBM生物学：基质细胞周围区、室管膜下神经生源性区和免疫微环境。GBM细胞和TME细胞呈相互反馈，导致肿瘤维持。这些细胞之间进行通信的一种方式是通过细胞外囊泡。这些囊泡包括有能力携带恶性和非恶性载荷的外泌体和微囊泡，例如miRNA、RNA、蛋白质、脂类和DNA。在本综述中，我们将讨论细胞外囊泡这一兴起的话题，以及它们作为GBM诊断和可靶向载体的新颖性。版权所有©2022 Elsevier Ltd.

Glioblastoma (GBM), is the most malignant form of gliomas and the most common and lethal primary brain tumor in adults. Conventional cancer treatments have limited to no efficacy on GBM. GBM cells respond and adapt to the surrounding brain parenchyma known as tumor microenvironment (TME) to promote tumor preservation. Among specific TME, there are 3 of particular interest for GBM biology: the perivascular niche, the subventricular zone neurogenic niche, and the immune microenvironment. GBM cells and TME cells present a reciprocal feedback which results in tumor maintenance. One way that these cells can communicate is through extracellular vesicles. These vesicles include exosomes and microvesicles that have the ability to carry both cancerous and non-cancerous cargo, such as miRNA, RNA, proteins, lipids, and DNA. In this review we will discuss the booming topic that is extracellular vesicles, and how they have the novelty to be a diagnostic and targetable vehicle for GBM.Copyright © 2022. Published by Elsevier Ltd.