线粒体是高度动态的细胞器，可以进行快速的形态适应，影响其数量、运输、细胞分布和功能，从而促进线粒体功能与细胞生理变化的整合。这些线粒体动态依赖于紧密调节的过程，如裂解、融合和附着到细胞骨架，它们的缺陷在各种病理生理条件下被观察到，包括癌症、心血管疾病和神经退行性疾病。多年来的各种研究已确定了关键分子参与者，并揭示了介导和调节这些过程的机制，并强调了它们的复杂性和特定于环境的性质。本综述聚焦于最近贡献于了解影响细胞中线粒体形态的过程，包括裂解、融合和转运的研究。版权所有 © 2022 Elsevier Ltd.

Mitochondria are highly dynamic organelles that undergo rapid morphological adaptations influencing their number, transport, cellular distribution, and function, which in turn facilitate the integration of mitochondrial function with physiological changes in the cell. These mitochondrial dynamics are dependent on tightly regulated processes such as fission, fusion, and attachment to the cytoskeleton, and their defects are observed in various pathophysiological conditions including cancer, cardiovascular disease, and neurodegeneration. Various studies over the years have identified key molecular players and uncovered the mechanisms that mediate and regulate these processes and have highlighted their complexity and context-specificity. This review focuses on the recent studies that have contributed to the understanding of processes that influence mitochondrial morphology including fission, fusion, and transport in the cell.Copyright © 2022 Elsevier Ltd. All rights reserved.