淋巴造血的传统模型将B和T细胞的发育过程呈现为在胎儿期开始，并分别在骨髓和胸腺中继续的线性过程。然而，与几十年前的报告不符，提示出生前后产生的淋巴细胞类型不同。在这方面，特定的γδ T细胞和使用Vγ3受体的细胞，以及先天型B-1 B细胞，更倾向于在胎儿血细胞的发育过程中产生。本综述综合了多个实验室的数据，重点关注我们使用的小鼠模型的研究结果，证明先天形态和传统形态的B和T细胞以不同方式调节、不依赖于造血干细胞的波动发育。这种淋巴细胞的分层发展对于理解成年人免疫系统的组成具有意义，并可能为各种淋巴白血病的起源提供见解。©2022 John Wiley＆Sons A / S。由John Wiley＆Sons Ltd出版。

Traditional models of lymphopoiesis present B and T cell development as a linear process that initiates in the fetus and continues after birth in the bone marrow and thymus, respectively. However, this view of lymphocyte development is not in accord with reports, dating back several decades, indicating that the types of lymphocytes generated before and after birth differ. In this regard, selected γδ T cells, and those that utilize the Vγ3 receptor in particular, and innate-like B-1 B cells preferentially arise during fetal blood cell development. This review synthesizes data from multiple laboratories, with an emphasis on our own work using mouse models, demonstrating that innate and conventional B and T cells emerge in hematopoietic stem cell independent and dependent waves of development that are differentially regulated. This layering of lymphocyte development has implications for understanding the composition of the adult immune system and may provide insights into the origin of various lymphocytic leukemias.© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.