间苯三酚及其衍生物是一种广泛分布于植物和褐藻中的大类次生代谢产物。许多生物活性，包括抗氧化剂、抗炎剂、抗微生物和抗癌剂，都与这一类化合物有关。本文分析了间苯三酚抗病毒和抗细菌能力的相关数据。其中一些化合物和衍生物在体外显示出重要的抗微生物活性。间苯三酚已显示出对人类免疫缺陷病毒（HIV）、疱疹或肠道病毒等病毒具有疗效，初步数据通过对接分析表明它们可能对SARS-CoV-19有效。此外，一些间苯三酚衍生物对不同细菌菌株表现出抗菌效果，包括枯草芽孢杆菌和金黄色葡萄球菌，部分半合成衍生物的开发已导致具有显著增强生物活性的间苯三酚。然而，这些化合物的治疗应用受到体内研究的不足和关于其作用机制的信息缺乏的限制，因此需要进一步的研究。在此基础上，我们的工作旨在收集关于天然和合成间苯三酚衍生物作为抗人类病原体的抗病毒和抗细菌剂的有效性的数据，这些数据已在过去三十年中发表。此次回顾中报道的结果是一份宝贵的最新信息来源，将有助于研究人员开发新的抗微生物剂。

Phloroglucinol and derived compounds comprise a huge class of secondary metabolites widely distributed in plants and brown algae. A vast array of biological activities, including antioxidant, anti-inflammatory, antimicrobial, and anticancer has been associated to this class of compounds. In this review, the available data on the antiviral and antibacterial capacity of phloroglucinols have been analyzed. Some of these compounds and derivatives show important antimicrobial properties in vitro. Phloroglucinols have been shown to be effective against viruses, such as human immunodeficiency virus (HIV), herpes or enterovirus, and preliminary data through docking analysis suggest that they can be effective against SARS-CoV-19. Also, some phloroglucinols derivatives have shown antibacterial effects against diverse bacteria strains, including Bacillus subtilis and Staphylococcus aureus, and (semi)synthetic development of novel compounds have led to phloroglucinols with a significantly increased biological activity. However, therapeutic use of these compounds is hindered by the absence of in vivo studies and scarcity of information on their mechanisms of action, and hence further research efforts are required. On the basis of this consideration, our work aims to gather data regarding the efficacy of natural-occurring and synthetic phloroglucinol derivatives as antiviral and antibacterial agents against human pathogens, which have been published during the last three decades. The recollection of results reported in this review represents a valuable source of updated information that will potentially help researchers in the development of novel antimicrobial agents.