重编程的新陈代谢是癌症的标志。然而，癌细胞的代谢依赖性包括肿瘤发生、疾病进展和治疗抵抗，需要一系列不同的重编程细胞代谢通路。这些通路包括有氧糖酵解、氧化磷酸化、活性氧物种产生、脱 novo 脂类合成、脂肪酸 β-氧化、氨基酸（尤其是谷氨酰胺）代谢以及线粒体代谢。本综述重点介绍了信号转导和激活转录因子（STAT）蛋白（尤其是STAT3、STAT5、STAT6和STAT1）在编排高度动态代谢方面的中心作用，不仅包括癌细胞，而且还包括肿瘤微环境中的免疫细胞和脂肪细胞。STAT蛋白能够塑造特定的代谢过程，通过传导代谢物、细胞因子、生长因子及其受体的信号，定义调节癌细胞和免疫细胞代谢协调的广泛分子的遗传程序，并在多个水平上调节线粒体活性，包括能量代谢和脂质介导的线粒体完整性。鉴于STAT蛋白在代谢状态调节中的中心作用，它们是改变癌症代谢重编程的潜在治疗靶点。©2023年 Springer Nature Limited.

Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of cancer, from tumour initiation through disease progression and therapy resistance, requires a spectrum of distinct reprogrammed cellular metabolic pathways. These pathways include aerobic glycolysis, oxidative phosphorylation, reactive oxygen species generation, de novo lipid synthesis, fatty acid β-oxidation, amino acid (notably glutamine) metabolism and mitochondrial metabolism. This Review highlights the central roles of signal transducer and activator of transcription (STAT) proteins, notably STAT3, STAT5, STAT6 and STAT1, in orchestrating the highly dynamic metabolism not only of cancer cells but also of immune cells and adipocytes in the tumour microenvironment. STAT proteins are able to shape distinct metabolic processes that regulate tumour progression and therapy resistance by transducing signals from metabolites, cytokines, growth factors and their receptors; defining genetic programmes that regulate a wide range of molecules involved in orchestration of metabolism in cancer and immune cells; and regulating mitochondrial activity at multiple levels, including energy metabolism and lipid-mediated mitochondrial integrity. Given the central role of STAT proteins in regulation of metabolic states, they are potential therapeutic targets for altering metabolic reprogramming in cancer.© 2023. Springer Nature Limited.