金属有机框架（MOFs）因具有将磁性纳米颗粒包裹在内，从而降低细胞毒性和高孔隙度，有利于化学药物封装等特性，成为癌症治疗和诊断的有吸引力的候选者。本研究合成了FeAu合金纳米颗粒（FeAu NPs），并涂覆了MIL-100（Fe）MOFs来制备FeAu @ MOF纳米结构体。我们在这些纳米结构体中封装了Doxorubicin，并评估了该平台用于医学成像和癌症诊断的适用性。FeAu @ MOF纳米结构体（FeAu @ MIL-100（Fe））表现出超顺磁性、磁致发热行为，并在交变磁场（AMF）刺激下分别显示出69.95%和97.19%的DOX封装和释放效率。体外实验表明，AMF诱导的高热致90% HSC-3口腔鳞状细胞癌细胞死亡，表明该应用于癌症诊断和治疗。最后，在小鼠体内模型中，FeAu @ MOF纳米结构体提高了图像对比度，使肿瘤体积减少了30倍，肿瘤重量减少了10倍，并显著增强了累积生存率，突显了该平台在口腔癌治疗方面的潜力。版权所有©2023 Elsevier Inc.发表。

Metal-organic frameworks (MOFs) have emerged as attractive candidates in cancer theranostics due to their ability to envelop magnetic nanoparticles, resulting in reduced cytotoxicity and high porosity, enabling chemodrug encapsulation. Here, FeAu alloy nanoparticles (FeAu NPs) are synthesized and coated with MIL-100(Fe) MOFs to fabricate FeAu@MOF nanostructures. We encapsulated Doxorubicin within the nanostructures and evaluated the suitability of this platform for medical imaging and cancer theranostics. FeAu@MOF nanostructures (FeAu@MIL-100(Fe)) exhibited superparamagnetism, magnetic hyperthermia behavior and displayed DOX encapsulation and release efficiency of 69.95 % and 97.19 %, respectively, when stimulated with alternating magnetic field (AMF). In-vitro experiments showed that AMF-induced hyperthermia resulted in 90 % HSC-3 oral squamous carcinoma cell death, indicating application in cancer theranostics. Finally, in an in-vivo mouse model, FeAu@MOF nanostructures improved image contrast, reduced tumor volume by 30-fold and tumor weight by 10-fold, which translated to enhancement in cumulative survival, highlighting the prospect of this platform for oral cancer treatment.Copyright © 2023. Published by Elsevier Inc.