纤维母细胞生长因子21（FGF21）是一种内分泌激素，控制着关键的代谢过程，并诱导合成葡萄糖转运蛋白，在脂肪细胞中增加葡萄糖吸收水平。它在多个代谢活跃的器官和组织中表达。FGF21也是葡萄糖稳态的一个强大调节因子，作为PPAR的一个直接下调基因，它在调节葡萄糖和脂质活性方面发挥作用。尝试了解与FGF21相关的各个方面，包括受体结合和基因组连锁图等属性，以及功能上调FGF21的基因信息，以及直接和间接下调在各种代谢途径中至关重要的基因的信息。此外，还观察了针对特定基因的各种基因调控分析，包括靶向FGF21的独特mi-RNAs和lnc-RNAs，以及常见的SNPs，这是细胞失调的常见原因，导致不同的代谢性疾病和癌症发病机制。FGF21与PPARγ之间的独特蛋白质相互作用和交流以及它们在代谢紊乱相关调节活动中的联合作用也被揭示出来。其作为各种心血管和代谢性疾病有效生物标志物的潜力和独特作用也得到了强调。本研究试图强调FGF21在过度表达和级联抑制后的多向作用，导致饮食性肥胖的诱导，并同时信号脂肪细胞吸收葡萄糖并降低三酰甘油和血糖水平的糖尿病模型（经行管理之后），使其成为几种代谢和心血管疾病的有前途的治疗方法。

Fibroblast growth factor 21 (FGF21) is an endocrine hormone that controls key metabolic processes and induces the synthesis of glucose transporters, resulting in increased glucose absorption levels in fat cells. It is expressed in multiple metabolically active organs and tissues. FGF21 is also a powerful regulator of glucose homeostasis as a direct downregulating gene of PPAR, which plays a role in regulating the activity of glucose and lipids. Attempts were made to understand various aspects related to FGF21, including properties like receptor binding and genomic linkage map, along with the information about the genes that function in the upregulation of FGF21 and how it, directly and indirectly, downregulates the genes that are vital in various metabolic pathways. Further, various gene regulatory analyses on the specific gene concerning unique mi-RNAs and lnc-RNAs that target FGF21 and alter its functioning along with SNPs were observed, that are the common cause of cell dysregulation, leading to different metabolic diseases and pathogenesis of cancer. Unique protein-protein interaction and crosstalk between FGF21 and PPARγ shed light on their combined role in metabolic disorder-related regulatory activities. Its potential and unique role as an effective biomarker for various cardiovascular and metabolic disorders have also been highlighted. This study attempts to highlight the pleiotropic role of FGF21 activity following its overexpression and inhibition of cascades that results in the induction of obesity from diet and simultaneously signals adipocytes to absorb glucose and decrease triglyceride and blood sugar levels in diabetic models (after administration), rendering it a promising treatment for several metabolic and cardiovascular disorders.