在美国，基于种族/族裔，晶体管转移性肾细胞癌患者与基于人口的对照组之间的总体生存差异。
Differences in overall survival between clear cell metastatic renal cell carcinoma patients versus population-based controls according to race/ethnicity in the United States.
发表日期：2023 Mar
作者：
Cristina Cano Garcia, Nancy Nimer, Mattia Luca Piccinelli, Stefano Tappero, Andrea Panunzio, Francesco Barletta, Reha-Baris Incesu, Zhe Tian, Fred Saad, Anil Kapoor, Alberto Briganti, Carlo Terrone, Shahrokh F Shariat, Derya Tilki, Alessandro Antonelli, Ottavio De Cobelli, Luis A Kluth, Andreas Becker, Felix K H Chun, Pierre I Karakiewicz
来源：
ANNALS OF EPIDEMIOLOGY
摘要：
为了量化清液型转移性肾细胞癌（ccmRCC）患者和年龄、性别匹配的基于人口的对照组之间的五年总生存率(OS)的差异，特别是考虑到种族/民族因素。我们依靠监测、流行病学和终点结果数据库(2006-2016)来确定新诊断的(2006-2011)白种人、西班牙裔、非洲裔美国人或亚洲/太平洋岛民种族/民族的ccmRCC患者。对于每个病例，我们使用社会安全管理机构生命表进行年龄和性别匹配的对照组(Monte Carlo模拟)，并进行五年的随访。我们比较了ccmRCC患者和对照组之间的OS。多元Cox回归模型测试种族/民族对OS的影响。
3067名ccmRCC患者中，2167人(71%)为白种人，488人(16%)为西班牙裔，216人(7%)为非洲裔美国人，196人(6%)为亚洲/太平洋岛民。五年后，ccmRCC患者和基于人口的对照组之间的OS差异在非洲裔美国人中最大(11 vs. 94%, Δ = 84%)，其次是西班牙裔(16 vs. 94%，Δ = 77%)，白种人(16 vs. 89%，Δ = 73%)和亚洲/太平洋岛民(19 vs. 88%，Δ = 70%)。在多元Cox回归模型中，非洲裔美国人表现出最高的死亡风险比(HR 1.3，p= 0.003)。相对于生命表衍生的年龄和性别匹配的对照组，ccmRCC患者的OS明显较差，尤其是在非洲裔美国人中。版权所有 © 2023 Elsevier Inc.
To quantify differences in five-year overall survival (OS) between clear cell metastatic renal cell carcinoma (ccmRCC) patients and age- and sex-matched population-based controls, especially when race/ethnicity is considered.We relied on the Surveillance, Epidemiology and End Results database (2006-2016) to identify newly diagnosed (2006- 2011) ccmRCC patients of either Caucasian, Hispanic, African American, or Asian/Pacific Islander race/ethnicity. For each case, we simulated an age- and sex-matched control (Monte Carlo simulation), relying on Social Security Administration Life Tables with five-year follow-up. We compared OS between ccmRCC patients and controls. Multivariable Cox regression models tested for race/ethnicity effect on OS.Of 3067 ccmRCC patients, 2167 (71%) were Caucasians vs. 488 (16%) Hispanics vs. 216 (7%) African Americans and 196 (6%) Asians/Pacific Islanders. At five years, OS difference between ccmRCC patients vs. population-based controls was greatest in African Americans (11 vs. 94%, Δ = 84%), followed by Hispanics (16 vs. 94%, Δ = 77%), Caucasians (16 vs. 89%, Δ = 73%) and Asians/Pacific Islanders (19 vs. 88%, Δ = 70%). In multivariable Cox regression models, African Americans exhibited highest Hazard Ratio for death (HR 1.3, p= 0.003).Relative to Life Tables' derived age- and sex-matched controls, ccmRCC patients exhibit drastically worse OS, especially African Americans.Copyright © 2023 Elsevier Inc. All rights reserved.