需要紧急开发非侵入式生物标记物来诊断口腔潜在恶性疾患(OPMD)。许多研究都探究了口腔潜在恶性疾患患者唾液中超过20种miRNA，但哪些miRNA对于口腔潜在恶性疾患的确诊和进展具有更好的鉴别能力仍不确定。总结了17个资格符合的研究，包括426例口腔潜在恶性疾患和486例对照对象（352例正常粘膜和134例口腔鳞状细胞癌）。泡泡图分析表明，与口腔潜在恶性疾患初发相关的最有效的唾液miRNA是miR-21，其次是miR-31和miR-142；与口腔潜在恶性疾患复发和恶性进展相关的最有效的miRNA是miR-31、miR-21和miR-184.唾液miRNA，特别是miR-21和miR-31，与口腔潜在恶性疾患的初发和进展均有关系，因此可以作为筛选OPMD和检测恶变的非侵入性生物标记物。 © 2022 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V.

There is an urgent need for noninvasive biomarkers to diagnose oral potentially malignant disorders (OPMD). A wide range of over 20 miRNAs in saliva of OPMD patients have been investigated in different studies. Yet, which of the ones provide a better power of discrimination for the diagnosis of OPMD onset and progression are uncertain.A total of 17 eligible studies including 426 cases of OPMD and 486 control subjects (352 normal mucosa and 134 oral squamous cell carcinoma) were summarized.The bubble chart analysis showed that the most power salivary miRNA associated with OPMD onset was miR-21, followed by miR-31 and miR-142; the better power miRNAs associated with recurrence and malignant progression of OPMD were miR-31, miR-21, and miR-184.Salivary miRNAs, especially miR-21 and miR-31, were associated with onset and progression of OPMD, and could then serve as noninvasive biomarkers for screening OPMD and detecting malignant changes.© 2022 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V.