随访芭蕾食管（BE）的内窥镜监测（Seattle协议活检）在常规实践中耗时且不充分，目前没有关于BE监测程序时间的建议。我们调查了具有足够组织采样的监测程序持续时间以及程序时间对发现异型增生率（DDR）的影响。我们进行了一个交叉随机对照试验的标准组后续分析，招募BE≥ C2和/或≥ M3且没有明显可见的异型增生病变的患者。在白光成像检查后，对隐约病变和Seattle协议活检进行针对性活检。根据BE长度对手术持续时间和活检数进行分层。用多元逻辑回归评估内窥镜相关变量对DDR的影响。共收集了142例患者，其中15例（10.6％）被诊断为高级别异型增生/粘膜内癌，15例（10.6％）为低级别异型增生。中位手术时间为16.5分钟（IQR 14.0-19.0）。我们发现，随着BE长度每增加1厘米，内窥镜持续时间增加0.9分钟。相比针对性活检，Seattle协议活检对发现异型增生的敏感性更高（86.7％与60.0％；p = 0.045）。更长的手术时间与四分之一活检的异型增生检出率增加有关（OR 1.10，95％CI 1.00-1.20，p = 0.04），对于BE> 6cm的患者，也与针对性活检的异型增生检出率增加有关（OR 1.21，95％CI 1.04-1.40；p = 0.01）。对于没有明显可见的异型增生病变的BE患者，手术时间越长，发现异型增生的可能性越高。需要充足的时间来进行良好质量的监测，以最大程度地发现异型增生。作者。这是由Thieme在创作共用许可证下发布的开放获取文章，允许无限制使用，分发和再制作，只要原作品得到适当引用。（https://creativecommons.org/licenses/by/4.0/）。

Endoscopic surveillance of Barrett's esophagus (BE) with Seattle protocol biopsies is time-consuming and inadequately performed in routine practice. There is no recommendation on procedural time for BE surveillance. We investigated the duration of surveillance procedures with adequate tissue sampling and the effect of procedural time on dysplasia detection rate (DDR).We performed post-hoc analysis from the standard arm of a cross-over randomized controlled trial recruiting patients with BE ≥C2 and/or ≥M3 and no clearly visible dysplastic lesions. After inspection with white-light imaging, targeted biopsies of subtle lesions and Seattle protocol biopsies were performed. Procedure duration and biopsy number were stratified by BE length. The effect of endoscopy related variables on DDR was assessed by multivariable logistic regression.Of 142 patients recruited, 15 (10.6%) received a diagnosis of high-grade dysplasia/intramucosal cancer and 15 (10.6%) low-grade dysplasia. The median procedural time was 16.5 minutes (IQR 14.0-19.0). We found endoscopy duration increased by 0.9 minutes for additional 1cm of BE length. Seattle protocol biopsies had higher sensitivity for dysplasia compared to targeted biopsies (86.7% vs. 60.0%; p=0.045). Longer procedural time was associated with increased likelihood of dysplasia detection on quadrantic biopsies (OR 1.10, 95%CI 1.00-1.20, p=0.04), and for patients with BE>6cm also on targeted biopsies (OR 1.21, 95% CI 1.04-1.40; p=0.01).In BE patients with no clearly visible dysplastic lesions, longer procedural time is associated with increased likelihood of dysplasia detection. Adequate time slots are required to perform good quality surveillance and maximise dysplasia detection.The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).