与其他乳腺癌亚型相比，目前三阴性乳腺癌（TNBC）的靶向治疗选择有限。大量研究表明，肿瘤微环境（TME）中的癌细胞、基质细胞和免疫细胞在TNBC进展中发挥了重要作用。因此，了解TNBC TME的组分和各种细胞群体之间的相互作用至关重要。本文回顾了通过单细胞技术鉴定出的TNBC TME的组分。此外，还讨论了细胞之间的分子相互作用和有助于TNBC进展的潜在治疗靶点。单细胞组学研究对TME中的细胞分类和识别参与肿瘤进展和治疗的重要细胞类型方面做出了贡献。TME中癌细胞与基质细胞/免疫细胞之间的相互作用已经发现了潜在的治疗靶点。具有空间和时间分辨率的实验数据将进一步促进对TNBC TME的认识。

In contrast to other breast cancer subtypes, there are currently limited options of targeted therapies for triple-negative breast cancer (TNBC). Immense research has demonstrated that not only cancer cells but also stromal cells and immune cells in the tumor microenvironment (TME) play significant roles in the progression of TNBC. It is thus critical to understand the components of the TME of TNBC and the interactions between the various cell populations.The components of the TME of TNBC identified by single-cell technologies are reviewed. Furthermore, the molecular interactions between the cells and the potential therapeutic targets contributing to the progression of TNBC are discussed.Single-cell omics studies have contributed to the classification of cells in the TME and the identification of important cell types involved in the progression and the treatment of the tumor. The interactions between cancer cells and stromal cells/immune cells in the TME have led to the discovery of potential therapeutic targets. Experimental data with spatial and temporal resolution will further boost the understanding of the TME of TNBC.