在狗身上自发性肿瘤与人类肿瘤之间存在重要的遗传和组织学相似性，使它们成为有价值的模型，以指导药物研发。然而，目前的翻译研究由于癌症结果分散在兽医诊所之间且几乎不进行基因组测试而受到限制。在本研究中，我们旨在通过系统性地表征肿瘤中的基因突变及其对靶向治疗的反应来扩展犬模型的价值。总共，我们收集和分析了2119只带瘤狗的存活结果以及1108只犬中基因组改变的预后影响。我们的分析确认了犬和人之间的某些关键癌基因，包括TP53和PIK3CA的预后一致性。我们还发现，用于人类的几种靶向治疗，在治疗带有特定基因组改变的犬的肿瘤时，与积极预后有关联，凸显了犬模型在推动个体化肿瘤学药物发现方面的价值。© 2023. The Author(s).

Spontaneous tumors in canines share significant genetic and histological similarities with human tumors, positioning them as valuable models to guide drug development. However, current translational studies have limited real world evidence as cancer outcomes are dispersed across veterinary clinics and genomic tests are rarely performed on dogs. In this study, we aim to expand the value of canine models by systematically characterizing genetic mutations in tumors and their response to targeted treatments. In total, we collect and analyze survival outcomes for 2119 tumor-bearing dogs and the prognostic effect of genomic alterations in a subset of 1108 dogs. Our analysis identifies prognostic concordance between canines and humans in several key oncogenes, including TP53 and PIK3CA. We also find that several targeted treatments designed for humans are associated with a positive prognosis when used to treat canine tumors with specific genomic alterations, underscoring the value of canine models in advancing drug discovery for personalized oncology.© 2023. The Author(s).