长期宫颈癌幸存者中与与健康相关的生活质量相关的可修改因素的研究
A study of modifiable factors associated with health-related quality of life in long-term cervical cancer survivors
影响因子:3.10000
分区:医学2区 / 妇产科学2区
发表日期:2023 Feb
作者:
Alv A Dahl, Anne Gry Bentzen, Sophie D Fosså, Siri Lothe Hess, Cecilie E Kiserud
摘要
癌症幸存者中与健康相关的生活质量（HR-QOL）与症状缓解和最佳护理有关。这项对长期宫颈癌幸存者的横断面研究的目的是两个方面：（a）将长期宫颈癌幸存者中的HR-QOL与参考数据进行比较； （b）在长期使用高HR-QOL作为参考的长期宫颈癌幸存者中，与低水平的通用癌症HR-QOL显着相关的可修改因素。为了获得同质样本，仅包括具有FIGO阶段1和2的女性。该问卷包括欧洲癌症生活质量研究和治疗的欧洲研究问卷。C-30（EORTC QLQ C-30）通用HR-QOL。 HR-QOL高和低HR-QOL的组通过一般HR-QOL项目的中位数定义。通过描述性统计数据检查了组间差异。逻辑回归分析检查了与低通用HR-QOL相关的自变量的逻辑回归分析。PleteC-30分数由472个长期宫颈癌幸存者提供。调查的中位年龄为53岁（四分位数14.9岁），诊断以来的中位时间为11（四分位数3.9）年。 1阶段疾病的幸存者比例为83％，第2阶段为17％。平均通用HR-QOL评分显示长期宫颈癌幸存者和参考证据之间的差异很小。在多变量分析中，仅可修改变量与低通用HR-QOL（即自我评估的健康，可能的抑郁症，疲劳和疼痛）保持显着相关。在双变量分析中，其他可修改的变量还显示出与低通用的HR-QOL的显着关联，例如可能的焦虑症，肥胖，吸烟，睡眠障碍和肠症状。Clinicians应该意识到，长期宫颈癌幸存者中的通用HR-QOL最终可能会通过整体上的鉴定和处理。
Abstract
Health-related quality of life (HR-QoL) in cancer survivors is relevant for symptom relief and optimal care. The aim of this cross-sectional study of long-term cervical cancer survivors was two-fold: (a) To compare HR-QoL in long-term cervical cancer survivors with reference data; and (b) to identify modifiable factors significantly associated with low levels of generic cancer HR-QoL in long-term cervical cancer survivors using high HR-QoL as reference.Women treated for cervical cancer from 2000 through 2007 who were cancer-free and alive in 2013 received a mailed questionnaire including scales for anxiety, depression, and HR-QoL. To obtain a homogeneous sample only women with FIGO stages 1 and 2 were included. The questionnaire included the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire.C-30 (EORTC QLQ C-30) for generic HR-QoL. Groups with high and low HR-QoL were defined by the median score on the general HR-QoL item. Between-group differences were examined with descriptive statistics. Logistic regression analyses examined independent variables associated with low generic HR-QoL.Complete C-30 scores were delivered by 472 long-term cervical cancer survivors. Median age at survey was 53 (interquartile range 14.9) years, and median time since diagnosis was 11 (interquartile range 3.9) years. The proportion of survivors with stage 1 disease was 83% and stage 2 was 17%. Mean generic HR-QoL scores showed minor differences between long-term cervical cancer survivors and reference data. In the multivariable analysis, only modifiable variables remained significantly associated with low generic HR-QoL namely self-rated health, probable depression, fatigue, and pain. In bivariate analyses other modifiable variables also showed significant associations with low generic HR-QoL like probable anxiety disorder, obesity, smoking, sleep disturbances, and bowel symptoms.Clinicians should be aware that generic HR-QoL in long-term cervical cancer survivors eventually may be improved by identification and treatment of modifiable factors through the whole follow-up period.