癌症幸存者的健康相关生命质量（HR-QoL）对于症状缓解和最佳护理是相关的。这项长期宫颈癌幸存者的横断面研究的目的是双重的：（a）比较长期宫颈癌幸存者的HR-QoL和参考数据；（b）使用高HR-QoL作为参考，确定与长期宫颈癌幸存者普通癌症HR-QoL水平低相关的可改变因素。 接受了2000年至2007年宫颈癌治疗且于2013年无癌症且仍在生者接收到一份邮寄的调查问卷，包括焦虑、抑郁和HR-QoL评分。为获取均匀样本，仅包括FIGO分期为1和2的妇女。问卷包括欧洲癌症研究与治疗组织生命质量问卷C-30（EORTC QLQ C-30）以评估普通HR-QoL。高HR-QoL和低HR-QoL组由普通HR-QoL项目的中位数得分定义。使用描述性统计方法检查组间差异。逻辑回归分析检查与普通HR-QoL低相关的独立变量。 共有472名长期宫颈癌幸存者完成了C-30评分。调查时的中位年龄为53岁（四分位数为14.9岁），自诊断以来的中位时间为11年（四分位数为3.9年）。1期疾病的幸存者比例为83％，2期为17％。长期宫颈癌幸存者的平均普通HR-QoL分数显示出微小差异与参考数据之间的差异。在多变量分析中，只有可变因素与普通HR-QoL低显著相关，即自我评价健康，可能的抑郁症，疲劳和疼痛。在双变量分析中，其他可变因素也显示出与低普通HR-QoL显著相关，如可能的焦虑症，肥胖，吸烟，睡眠障碍和肠道症状。 临床医生应意识到，长期宫颈癌幸存者的普通HR-QoL最终可以通过在整个随访期间识别和治疗可变因素来改善。 ©2022作者。由约翰·威立·爱斯克公司（John Wiley＆Sons Ltd）代表北欧产科学会（NFOG）出版的《产科和妇科学报》。

Health-related quality of life (HR-QoL) in cancer survivors is relevant for symptom relief and optimal care. The aim of this cross-sectional study of long-term cervical cancer survivors was two-fold: (a) To compare HR-QoL in long-term cervical cancer survivors with reference data; and (b) to identify modifiable factors significantly associated with low levels of generic cancer HR-QoL in long-term cervical cancer survivors using high HR-QoL as reference.Women treated for cervical cancer from 2000 through 2007 who were cancer-free and alive in 2013 received a mailed questionnaire including scales for anxiety, depression, and HR-QoL. To obtain a homogeneous sample only women with FIGO stages 1 and 2 were included. The questionnaire included the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire.C-30 (EORTC QLQ C-30) for generic HR-QoL. Groups with high and low HR-QoL were defined by the median score on the general HR-QoL item. Between-group differences were examined with descriptive statistics. Logistic regression analyses examined independent variables associated with low generic HR-QoL.Complete C-30 scores were delivered by 472 long-term cervical cancer survivors. Median age at survey was 53 (interquartile range 14.9) years, and median time since diagnosis was 11 (interquartile range 3.9) years. The proportion of survivors with stage 1 disease was 83% and stage 2 was 17%. Mean generic HR-QoL scores showed minor differences between long-term cervical cancer survivors and reference data. In the multivariable analysis, only modifiable variables remained significantly associated with low generic HR-QoL namely self-rated health, probable depression, fatigue, and pain. In bivariate analyses other modifiable variables also showed significant associations with low generic HR-QoL like probable anxiety disorder, obesity, smoking, sleep disturbances, and bowel symptoms.Clinicians should be aware that generic HR-QoL in long-term cervical cancer survivors eventually may be improved by identification and treatment of modifiable factors through the whole follow-up period.© 2022 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).