新兴的等离子纳米颗粒及其用于癌症放射疗法的组件
Emerging plasmonic nanoparticles and their assemblies for cancer radiotherapy
影响因子:17.60000
分区:医学1区 Top / 药学1区
发表日期:2023 Mar
作者:
Ying Wu, Kang Zhu, Xuan Zhang, Wei Du, Jibin Song, Huanghao Yang
摘要
在过去的几十年中，等离子体纳米颗粒及其组件已被广泛用于生物传感，光学成像和生物医学。特别是在放射疗法领域，高Z等离激元纳米材料的物理化学特性赋予了它们具有敏感放射疗法的能力。与单个颗粒相比，具有可调特性的组装结构导致药物输送和癌症治疗中的多功能应用。在这篇综述中，我们专注于等离子纳米颗粒及其用于癌症放射疗法的组件。首先，简要引入了等离子放射敏剂的敏化机制。随后，根据结构和形状分类，系统地讨论了癌症放射疗法的最新进展。最后，还详细讨论了该领域的当前挑战和未来观点。
Abstract
Plasmonic nanoparticles and their assemblies have been widely used in biosensing, optical imaging, and biomedicine over the past few decades. Especially in the field of radiotherapy, the physicochemical properties of high-Z plasmonic nanomaterials endow them with the ability to sensitize radiotherapy. Compared with single particles, the assembled structure with tunable properties leads to versatile applications in drug delivery and cancer treatment. In this review, we focus on plasmonic nanoparticles and their assemblies for cancer radiotherapy. First, the sensitization mechanism of plasmonic radiosensitizers is briefly introduced. Subsequently, the recent progress in cancer radiotherapy is systematically discussed according to the structure and shape classification. Finally, the current challenges and future perspectives in this field are also discussed in detail.