我们采用了一种新颖的平均寿命缩短（ALSS）测量方法，研究了在2006年至2016年这10年间，在北美、欧洲、亚洲和大洋洲等20个高收入国家所选择的癌症患者中，寿命变化的情况。我们从世界卫生组织的死亡率数据库中获取了每个国家的癌症死亡数据。我们将ALSS计算为失去寿命年数与癌症患者的预期寿命之比。在研究期间内，我们发现许多国家整体癌症死亡人数的ALSS有些微小的变化。男性任何类型癌症ALSS的变化范围为-1.7至+0.4个百分点（pps），女性为-1.9至+0.6pps。在各国中，整体癌症死亡导致男性失去寿命的平均百分比为16%至22%，女性为18%至24%。在不同癌症类型中，中枢神经系统癌症的患者失去的寿命比例较大。在本研究中，我们展示了在所选的高收入国家中使用ALSS的方法，这有助于对癌症患者的过早死亡进行人群水平评估。版权所有©2023 Elsevier公司出版。

We applied a novel measure of average lifespan shortened (ALSS) to examine changes in lifespan among patients who died of cancer over a 10-year period from 2006 to 2016 in 20 selected high-income countries from North America, Europe, Asia, and Oceania.We retrieved cancer deaths in each country from the World Health Organization mortality database. We calculated ALSS as a ratio of years of life lost to the expected lifespan among patients who died from cancer.Between 2006 and 2016, we observed modest changes in ALSS for overall cancer deaths over the study in many countries. The changes in the ALSS over time due to any cancer ranged between -1.7 and +0.4 percentage points (pps) among men and between -1.9 and +0.6 pps among women. Across countries, overall cancer deaths led to an average loss between 16% and 22% of their lifespan in men, and between 18% and 24% in women. Across cancer sites, patients who died of central nervous system cancers, for instance, lost a large proportion of their lifespan.In this study, we demonstrated the use of ALSS across selected high-income countries, which enables population-level assessment of premature mortality among cancer patients over time.Copyright © 2023. Published by Elsevier Inc.