更好地了解癌症转移调控机制对于开发新疗法和降低死亡率至关重要。新出现的证据表明，肿瘤细胞和宿主免疫系统之间的相互作用在建立转移中发挥重要作用。肿瘤细胞能够招募免疫细胞，从而促进肿瘤细胞的入侵、血管内侵入、循环中的存活、血管外侵出以及在不同器官中的定居生长。肿瘤-宿主免疫互动还在远处器官产生一种促进转移的预转移微环境。在本文中，我们总结了关于肿瘤细胞和免疫细胞如何相互调节并促进转移形成在主要转移器官部位的最近发现。

A better understanding of the mechanisms regulating cancer metastasis is critical to develop new therapies and decrease mortality. Emerging evidence suggests that the interactions between tumor cells and the host immune system play important roles in establishing metastasis. Tumor cells are able to recruit immune cells, which in turn promotes tumor cell invasion, intravasation, survival in circulation, extravasation, and colonization in different organs. The tumor-host immunological interactions also generate a pre-metastatic niche in distant organs which facilitates metastasis. In this review, we summarize the recent findings on how tumor cells and immune cells regulate each other to co-evolve and promote the formation of metastases at the major organ sites of metastasis.