肿瘤的发展受循环代谢产物的影响，大多数肿瘤暴露于显著升高的乳酸和低水平的营养素（如葡萄糖和谷氨酰胺）水平。来源于肿瘤细胞的乳酸，是主要的循环碳代谢产物，它可以调节能量代谢和癌细胞信号通路，同时也作为能源和信号分子。最近的研究取得了有关乳酸和其代谢的促肿瘤作用的新见解。这些见解表明，利用靶向致癌代谢产物乳酸的抗肿瘤治疗策略，可以提高肿瘤代谢抑制剂的疗效和临床安全性。本综述描述了肿瘤乳酸的多功能作用及其代谢靶点治疗方法，包括乳酸脱氢酶和单羧酸转运体等，用于抗癌治疗。© 2023. 韩国药学会。

Tumor development is influenced by circulating metabolites and most tumors are exposed to substantially elevated levels of lactic acid and low levels of nutrients, such as glucose and glutamine. Tumor-derived lactic acid, the major circulating carbon metabolite, regulates energy metabolism and cancer cell signaling pathways, while also acting as an energy source and signaling molecule. Recent studies have yielded new insights into the pro-tumorigenic action of lactic acid and its metabolism. These insights suggest an anti-tumor therapeutic strategy targeting the oncometabolite lactic acid, with the aim of improving the efficacy and clinical safety of tumor metabolism inhibitors. This review describes the current understanding of the multifunctional roles of tumor lactic acid, as well as therapeutic approaches targeting lactic acid metabolism, including lactate dehydrogenase and monocarboxylate transporters, for anti-cancer therapy.© 2023. The Pharmaceutical Society of Korea.