我们使用SEER数据库评估了1975年至2017年间美国妇科癌症（包括宫颈、子宫、卵巢、阴道、外阴和其他）对女性的潜在失去寿命（PYLL）。我们还着重介绍了由妇科恶性肿瘤引起的种族差异和经济成本。在考虑肿瘤部位后，计算了年龄在75岁及以下的PYLL（75 - （诊断年龄+总体生存率））。采用Kruskal-Wallis H非参数方法进行了亚组比较，并使用后续分析。采用线性回归模型计算每五年的增量趋势。通过将死亡数据与年龄调整的估计寿命总生产力相乘，计算出生产力损失。我们共纳入了304,995名患者，从1975年至2017年共计1,472,152.67 PYLL。宫颈癌的中位PYLL（12.58年）高于其他妇科恶性肿瘤（分别为子宫癌0.83年、卵巢癌6.00年、阴道癌0.67年和外阴癌-0.25年）。对于子宫、卵巢和外阴癌，非西班牙裔白人（NHW）群体的中位PYLL低于其他种族女性。1975年至2017年，整个队列的中位PYLL趋势呈稳步上升趋势（p <0.001，B1 = 1.65年）。宫颈癌的上升速度最为迅速（p <0.001，B1 = 2.68年），西班牙裔群体的上升速度最快（p <0.001，B1 = 1.92）。整个周期的总生产力损失为790亿美元，其中子宫癌和非西班牙裔白人群体的损失最大。我们是第一篇分析妇科恶性肿瘤PYLL并估算由于过早死亡而产生的生产力损失的研究。数据表明存在明显的种族和民族差异趋势。版权所有©2023 Elsevier Inc。保留所有权利。

We assessed potential years of life lost (PYLL) in women secondary to gynecologic cancers (cervical, uterine, ovarian, vaginal, vulvar, and other) in the United States from 1975 to 2017 using SEER database. We also highlight racial disparities and economic costs of mortality from gynecologic malignancies.PYLL up to and including age 75 years were calculated [75 - (age at diagnosis + overall survival)] after stratifying for tumor site. Subgroup comparison was done using nonparametric method Kruskal-Wallis H with post-hoc analysis. Linear regression model was used to calculate every five-year incremental trends. Productivity losses were calculated using mortality data multiplied by age-adjusted estimated total lifetime productivity.Total 304,995 patients were included with 1,472,152.67 PYLL from 1975 to 2017. Median PYLL for cervical cancer (12.58 years) was higher than other gynecologic malignancies (0.83, 6.00, 0.67 and - 0.25 years respectively for uterine, ovarian, vaginal and vulvar cancers). The median PYLL for Non-Hispanic White (NHW) population was lower than women from other racial groups for uterine, ovarian and vulvar cancers. From 1975 to 2017, median PYLL trend in the entire cohort showed a steady increment (p < 0.001, B1 = 1.65 years). Most rapid rise was noted in cervical cancer (p < 0.001, B1 = 2.68 years) and Hispanic population (p < 0.001, B1 = 1.92). Total productivity loss was $79 billion during 1975-2017 with maximum loss seen in uterine cancer and NHW population.Ours is the first study to analyze PYLL in gynecologic malignancies and estimate productivity losses due to premature deaths. Data shows a clear trend pointing towards racial and ethnic disparities.Copyright © 2023 Elsevier Inc. All rights reserved.