机械治疗被提出作为癌症治疗的新选择。越来越多的证据表明，与正常细胞相比，癌细胞的核力学和机械转导存在特征差异。对核力学和机械转导的理解最新进展，不仅为恶性转化过程提供更深入的洞察，而且为开发新的治疗方法提供有用的参考。在此，我们概述癌细胞核力学和机械转导的改变，并强调它们在癌症机械治疗中的意义。版权所有© 2023 Elsevier B.V.。

Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence suggests that characteristic differences are present in the nuclear mechanics and mechanotransduction of cancer cells compared with those of normal cells. Recent advances in understanding nuclear mechanics and mechanotransduction provide not only further insights into the process of malignant transformation but also useful references for developing new therapeutic approaches. Herein, we present an overview of the alterations of nuclear mechanics and mechanotransduction in cancer cells and highlight their implications in cancer mechanotherapy.Copyright © 2023 Elsevier B.V. All rights reserved.