肿瘤学中的机械疗法：靶向核力学和机械转导
Mechanotherapy in oncology: Targeting nuclear mechanics and mechanotransduction
影响因子:17.60000
分区:医学1区 Top / 药学1区
发表日期:2023 Mar
作者:
Shaobao Liu, Yuan Li, Yuan Hong, Ming Wang, Hao Zhang, Jinlu Ma, Kai Qu, Guoyou Huang, Tian Jian Lu
摘要
提出了机械疗法作为癌症治疗的新选择。越来越多的证据表明，与正常细胞相比，核力学和癌细胞的机械传导存在特征差异。理解核力学和机械转移的最新进展不仅提供了对恶性转化过程的进一步见解，而且还提供了开发新的治疗方法的有用参考。在此，我们概述了癌细胞中核力学和机械转导的改变，并强调了它们在癌症机械疗法中的影响。
Abstract
Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence suggests that characteristic differences are present in the nuclear mechanics and mechanotransduction of cancer cells compared with those of normal cells. Recent advances in understanding nuclear mechanics and mechanotransduction provide not only further insights into the process of malignant transformation but also useful references for developing new therapeutic approaches. Herein, we present an overview of the alterations of nuclear mechanics and mechanotransduction in cancer cells and highlight their implications in cancer mechanotherapy.