乳腺摄影筛查能检测出大部分的乳腺癌，但仍有部分女性在年度乳腺摄影检查之间被诊断为乳腺癌。我们旨在确定区分筛查检测乳腺癌和间隔癌的特征。对于我们机构在2013年7月1日至2020年6月30日期间进行的所有筛查乳腺摄影（n = 211,517）进行回顾。纳入在筛查后一年内诊断为乳腺癌的患者，并将其分为两个不同的组别：筛查检测组和间隔检测组。这些组别的特征使用卡方检验，费舍尔检验和学生t检验进行比较。总共纳入了1,232名患者（平均年龄64岁+/-11）。筛查乳腺摄影的敏感性为92%（1,136例筛查检测乳腺癌，96例间隔癌）。两组患者的年龄，种族和个人乳腺癌病史相似（p > 0.05）。间隔癌的患者更常出现乳腺组织密度高（75/96 = 78% vs 694/1136 = 61%，p<0.001）。与筛查检测癌症相比，间隔检测癌症更常见于一级及以上原发肿瘤（41/96 = 43% vs 139/1136 = 12%，p < 0.001）和一级及以上区域淋巴结（21/96 = 22% vs 132/1136 = 12%，p = 0.003）。间隔癌更常为三阴性癌（16/77 = 21% vs [48/813 = 6%]，p<0.001）且Ki67增殖指数较高（28/45 = 62% vs 188/492 = 38%，p=0.002）。乳腺摄影筛查对于乳腺癌的检测具有较高的敏感性（92%）。间隔癌与乳腺密度高相关，且具有较高的分期，分子特征较劣，与筛查检测癌症相比没有明显优势。©2023 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

Mammographic screening detects most breast cancers but there are still women diagnosed with breast cancer between annual mammograms. We aim to identify features that differentiate screen detected breast cancers from interval breast cancer.All screening mammograms (n = 211,517) performed 7/1/2013-6/30/2020 at our institution were reviewed. Patients with breast cancer diagnosed within one year of screening were included and divided into two distinct groups: screen detected cancer group and interval cancer group. Characteristics in these groups were compared using the chi square test, fisher test, and student's T test.A total of 1,232 patients were included (mean age 64 +/- 11). Sensitivity of screening mammography was 92% (1,136 screen detected cancers, 96 interval cancers). Patient age, race, and personal history of breast cancer were similar between the groups (p > 0.05). Patients with interval cancers more often had dense breast tissue (75/96 = 78% versus 694/1136 = 61%, p < 0.001). Compared to screen detected cancers, interval cancers were more often primary tumor stage two or higher (41/96 = 43% versus 139/1136 = 12%, p < 0.001) and regional lymph node stage one or higher (21/96 = 22% versus 132/1136 = 12%, p = 0.003). Interval cancers were more often triple negative (16/77 = 21% versus [48/813 = 6%], p < 0.001) with high Ki67 proliferation indices (28/45 = 62% versus 188/492 = 38%, p = 0.002).Mammographic screening had high sensitivity for breast cancer detection (92%). Interval cancers were associated with dense breast tissue and had higher stage with less favorable molecular features compared to screen detected cancers.Copyright © 2023 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.