磁场（MFs）与生物系统之间的相互作用机制长期以来一直隐藏在百年之内， 现在却继续吸引来自不同学科的研究人员的关注：物理、生物学、医学和生命科学。 在细胞水平揭示这些机制将有助于理解复杂的细胞系统， 并有助于解释和预测细胞对不同强度、方向和空间分布的MFs的反应，干预对生物体对MFs的反应。 我们建议通过MFs与细胞膜上的生物磁性和非生物磁性纳米粒子链相互作用来探讨MF对内皮细胞和癌细胞的影响的几种新物理机制。揭示的机制在创建生物体对外部应用的MFs的生理反应方面可能会扮演迄今未曾预料到的角色。 我们还有一组理论模型，可以预测细胞如何个别地和集体地对MF暴露做出反应。讨论了在健康和疾病中生物体对MF - 细胞相互作用的生理序列。所描述的效应及其基础机制是普遍的，并应发生在MF生物效应的大家族中。 这些结果对于进一步发展细胞生物学、细胞治疗和医学的新方法具有重要意义。版权所有© 2023作者。由Elsevier B.V.出版。保留所有权利。

The interaction mechanisms between magnetic fields (MFs) and living systems, which remained hidden for more than a hundred years, continue to attract the attention of researchers from various disciplines: physics, biology, medicine, and life sciences. Revealing these mechanisms at the cellular level would allow to understand complex cell systems and could help to explain and predict cell responses to MFs, intervene in organisms' reactions to MFs of different strengths, directions, and spatial distributions. We suggest several new physical mechanisms of the MF impacts on endothelial and cancer cells by the MF interaction with chains of biogenic and non-biogenic magnetic nanoparticles on cell membranes. The revealed mechanisms can play a hitherto unexpected role in creating physiological responses of organisms to externally applied MFs. We have also a set of theoretical models that can predict how cells will individually and collectively respond to a MF exposure. The physiological sequences of the MF - cell interactions for organisms in health and disease are discussed. The described effects and their underlying mechanisms are general and should take place in a large family of biological effects of MFs. The results are of great importance for further developing novel approaches in cell biology, cell therapy and medicine.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.