用于成像引导癌症治疗的可活化双功能分子剂
Activatable dual-functional molecular agents for imaging-guided cancer therapy
影响因子:17.60000
分区:医学1区 Top / 药学1区
发表日期:2023 Apr
作者:
Peng Zhang, Yaowei Zhu, Chunsheng Xiao, Xuesi Chen
摘要
Theranostics由于能够将癌症的实时诊断与有效的治疗方式相结合，因此引起了极大的关注。可以通过共价结合成像剂，治疗剂，刺激反应性接头和/或将靶向分子一起共价性双功能分子剂。可以通过在肿瘤部位过表达的生理刺激或外部触发器来选择性地激活它们，以释放成像剂和细胞毒性药物，从而为肿瘤成像和治疗提供许多优势，例如高信噪比，低系统性毒性，低全身毒性和改善的治疗效果。这篇综述总结了对癌症疗法的各种生理或外部刺激反应的双功能分子剂的最新进展。详细阐述了这些分子剂的分子设计，合成策略，可激活的机制和生物医学应用，然后简要讨论该领域的挑战和机会。
Abstract
Theranostics has attracted great attention due to its ability to combine the real-time diagnosis of cancers with efficient treatment modalities. Activatable dual-functional molecular agents could be synthesized by covalently conjugating imaging agents, therapeutic agents, stimuli-responsive linkers and/or targeting molecules together. They could be selectively activated by overexpressed physiological stimuli or external triggers at the tumor sites to release imaging agents and cytotoxic drugs, thus offering many advantages for tumor imaging and therapy, such as a high signal-to-noise ratio, low systemic toxicity, and improved therapeutic effects. This review summarizes the recent advances of dual-functional molecular agents that respond to various physiological or external stimuli for cancer theranostics. The molecular designs, synthetic strategies, activatable mechanisms, and biomedical applications of these molecular agents are elaborated, followed by a brief discussion of the challenges and opportunities in this field.