胃癌（GC）通常在晚期才被诊断出来，因此患者预后较差。这意味着早期发现这种癌症将会改善患者的预后和生存率。本系统综述探讨了循环蛋白质和代谢物生物标志物与GC发展的关联。在Medline、Embase、Cochrane Library和Web of Science数据库中进行文献检索，检索截止日期为2021年11月。如果文献评估了血液、尿液或唾液中的循环蛋白质和代谢物，并确定了它们与GC风险的关联，则将其纳入研究范围内。使用Newcastle-Ottawa量表评估确定的研究的质量，对队列研究进行随机和固定效应的Meta分析以计算汇总奥斯比比率。共纳入53项研究。高水平的抗幽门螺杆菌IgG水平、胃蛋白酶原I（PGI）<30μg/L和血清胃蛋白酶原I /胃蛋白酶原II（PGI / II）比值<3与GC发病风险呈正相关（汇总奥斯比比率（OR）分别为2.70; 95% CI：1.44-5.04、5.96; 95% CI：2.65-13.42和4.43; 95% CI：3.04-6.47）。此外，铁蛋白、铁和转铁蛋白水平与发展GC的风险之间呈反比关系（OR：0.62；95% CI：0.38-1, 0.97；95% CI：0.94-1和0.85；95% CI：0.76-0.94）。然而，葡萄糖、胆固醇、维生素C、维生素B12、维生素A、α-胡萝卜素、β-胡萝卜素、α-生育酚、γ-生育酚与GC风险之间无关联。汇总分析表明，高水平的抗幽门螺杆菌IgG、PGI <30μg/L和血清PGI / II比值<3以及低水平的铁蛋白、铁和转铁蛋白与GC风 险相关。© 2023 Elsevier Inc.。

Gastric cancer (GC) is often diagnosed at an advanced stage and thus patients have a poor prognosis. This implies that early detection of this cancer will improve patient prognosis and survival. This systematic review explored the association of circulating protein and metabolite biomarkers with GC development.A literature search was conducted until November 2021 on Medline, Embase, Cochrane library, and Web of Science databases. Studies were included if they assessed circulating proteins and metabolites in blood, urine, or saliva and determined their association with GC risk. Quality of identified studies was determined using the Newcastle-Ottawa scale for cohort studies. Random and fixed effects meta-analyses were performed to calculate pooled odds ratio.A total of 53 studies were included. High levels of anti-Helicobacter pylORi IgG levels, pepsinogen I (PGI) <30 µg/L and serum pepsinogen I/ pepsinogen II (PGI/II) ratio<3 were positively associated with risk of developing GC (pooled odds ratio (OR): 2.70; 95% CI: 1.44-5.04, 5.96, 95% CI: 2.65-13.42 and 4.43; 95% CI: 3.04-6.47). In addition, an inverse relationship was found between ferritin, iron and transferrin levels and risk of developing GC (OR: 0.62; 95% CI: 0.38-1,0.97; 95% CI: 0.94-1 and 0.85; 95% CI: 0.76-0.94). However, there was no association between levels of glucose, cholesterol, vitamin C, vitamin B12, vitamin A, α-Carotene, β-Carotene, α-Tocopherol, γ-Tocopherol, and GC risk.The pooled analysis demonstrated that high levels of anti-Helicobacter pylORi IgG, PGI<30µg/L and serum PGI/II ratio <3 and low levels of ferritin, iron and transferrin were associated with risk of GC.Copyright © 2023. Published by Elsevier Inc.