肿瘤进展基因2（TPL2）：从炎症到慢性肝病的“Cot-plicated”进展。
Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease.
发表日期：2023 Feb 08
作者：
Alejandro H Gutierrez, Marina S Mazariegos, Susana Alemany, Yulia A Nevzorova, Francisco Javier Cubero, Carlos Sanz-García
来源：
Bba-Mol Basis Dis
摘要：
细胞质蛋白肿瘤进展定位2（TPL2）又称癌症大阪甲状腺腺（Cot）或MAP3K8，在多种癌症和疾病中发挥重要作用，是炎症介质表达激活通路的关键组成部分。尽管炎症与TPL2之间存在着密切联系，但其在慢性肝病（CLD）中的功能尚未得到广泛研究，而CLD是全球发病率和死亡率的主要原因。在这里，我们详细分析TPL2在CLD中的重要性，以阐明TPL2在CLD进展过程中的病理和分子传导模式。这可能会产生重大进展，并推动CLD的诊断和治疗。版权所有 ©2023年作者。由Elsevier B.V.出版。保留所有权利。
The cytoplasmic protein tumor progression locus 2 (TPL2), also known as cancer Osaka thyroid (Cot), or MAP3K8, is thought to have a significant role in a variety of cancers and illnesses and it is a key component in the activation pathway for the expression of inflammatory mediators. Despite the tight connection between inflammation and TPL2, its function has not been extensively studied in chronic liver disease (CLD), a major cause of morbidity and mortality worldwide. Here, we analyze more in detail the significance of TPL2 in CLD to shed light on the pathological and molecular transduction pattern of TPL2 during the progression of CLD. This might result in important advancements and enable progress in the diagnosis and treatment of CLD.Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.