目前，癌症治疗主要包括外科手术，放疗，化疗，免疫疗法和分子靶向疗法，其中放疗是主要治疗手段之一。然而，放射疗法耐受性的发生很大程度上限制了其治疗效果。代谢重编程是癌症进展和治疗抵抗的一个重要标志。在放疗中，DNA断裂是细胞受损伤的主要机制，而癌细胞则易于增加葡萄糖、谷氨酰胺、丝氨酸、精氨酸、脂肪酸等代谢通量，从而为DNA损伤修复提供充足的底物和能量。因此，研究代谢重编程和癌症放疗耐受性之间的关联，可能为提高肿瘤治疗的疗效提供新思路。本综述主要关注代谢改变，包括葡萄糖、氨基酸、脂类、核苷酸和其他离子代谢在放射耐受性中的作用，并提出可能的治疗靶点，以提高癌症放疗的疗效。©作者（们）。

Currently, cancer treatment mainly consists of surgery, radiotherapy, chemotherapy, immunotherapy, and molecular targeted therapy, of which radiotherapy is one of the major pillars. However, the occurrence of radioresistance largely limits its therapeutic effect. Metabolic reprogramming is an important hallmark in cancer progression and treatment resistance. In radiotherapy, DNA breakage is the major mechanism of cell damage, and in turn, cancer cells are prone to increase the metabolic flux of glucose, glutamine, serine, arginine, fatty acids etc., thus providing sufficient substrates and energy for DNA damage repair. Therefore, studying the linkage between metabolic reprogramming and cancer radioresistance may provide new ideas for improving the efficacy of tumor therapy. This review mainly focuses on the role of metabolic alterations, including glucose, amino acid, lipid, nucleotide and other ion metabolism, in radioresistance, and proposes possible therapeutic targets to improve the efficacy of cancer radiotherapy.© The author(s).