单克隆球蛋白尚未确定意义（MGUS）是多发性骨髓瘤的前兆，其出现率超过70岁及以上成年人的5％，这是一个具有多病发生率的人群。MGUS通常在病人因与疾病无关的原因寻求治疗时偶然被诊断出来。我们的研究旨在研究MGUS患者的多病发生模式，因为总体健康状况可能会影响患者护理和MGUS监测的优先顺序。我们研究了429名已被诊断为MGUS（2007-2015）和1287个配对对照组的患者的多病发生模式。在诊断/索引日期，使用由美国Centers for Medicare和Medicaid慢性疾病仓库开发的算法定义了27个疾病。个体、二元组和三元组的常见共病模式在MGUS病例和对照组之间进行了比较。我们进行了潜在类别分析，以仅诊断出的病例中识别共病模式。我们还研究了在研究期间癌症发展的32名MGUS病例的共病模式。在MGUS病例和对照组中，最常见的共病包括高血压和高脂血症。贫血（病例：43％；对照组：16％）和慢性肾脏疾病（CKD;病例：36％；对照组：18％）及其二元组和三元组在病例中更常见。潜在类别分析在MGUS病例中识别出三类共病模式：高血压-高脂血症加贫血和CKD（31％）；低共病负荷（17％）；仅高血压-高脂血症（52％）。病例中贫血和CKD更高的患病率可能涉及MGUS的发病机制或监测，需要进一步研究。© 2023 UICC。

Monoclonal gammopathy of undetermined significance (MGUS), a precursor to multiple myeloma, is present in over 5% of adults aged 70 and older, a population with a high prevalence of multimorbidity. MGUS is often diagnosed incidentally when patients seek care for unrelated conditions. Our study sought to examine patterns of multimorbidity among MGUS patients, as overall health may impact patient care and the prioritization of MGUS surveillance. We examined patterns of comorbidities in 429 patients diagnosed with MGUS (2007-2015) and 1287 matched controls. Twenty-seven conditions were defined at diagnosis/index date using algorithms developed by the Centers for Medicare and Medicaid Chronic Conditions Warehouse. Patterns of common comorbidities were identified individually, in dyads and triads, and compared between MGUS cases and controls. We conducted a latent class analysis to identify comorbidity patterns among cases only. We also examined comorbidity patterns among a subset of 32 MGUS cases who progressed to cancer during the study period. The most common comorbidities among both MGUS cases and controls included hypertension and hyperlipidemia. Anemia (cases: 43%; controls: 16%) and chronic kidney disease (CKD; cases: 36%; controls: 18%), and dyads and triads containing those conditions, were more common among cases. Latent class analysis identified three classes of comorbidity among MGUS cases: hypertension-hyperlipidemia plus anemia and CKD (31%); low comorbidity burden (17%); and hypertension-hyperlipidemia alone (52%). The higher prevalence among cases of anemia and CKD, which may be involved in the pathogenesis of, or surveillance for, MGUS, warrants additional investigation.© 2023 UICC.