高动态范围双模式白光成像提高了新辅助治疗乳腺癌后肿瘤床采样的准确性
High Dynamic Range Dual-Modal White Light Imaging Improves the Accuracy of Tumor Bed Sampling After Neoadjuvant Therapy for Breast Cancer
影响因子:1.90000
分区:医学4区 / 病理学3区
发表日期:2023 Mar 13
作者:
Meng Zhang, Jun Liao, Zhanli Jia, Chenchen Qin, Lingling Zhang, Han Wang, Yao Liu, Cheng Jiang, Mengxue Han, Jinze Li, Kun Wang, Xinran Wang, Hong Bu, Jianhua Yao, Yueping Liu
摘要
由于缺乏适当的肿瘤床采样技术，对残留癌症负担的准确评估仍然具有挑战性。这项研究评估了白光成像系统的应用，以帮助病理学家区分样品中肿瘤床的成分和位置。高动态范围双模式白光成像（HDR-DWI）系统被开发出来捕获反射反射和Multiexposoly HDR HDR传输图像。在新辅助治疗后，它在60种改良的自由基乳房切除术中进行了测试。我们观察到肿瘤组织，纤维化组织和脂肪组织之间的差异透射率。将HDR-DWI的灵敏度和特异性与X射线或视觉检查进行了比较，以确定HDR-DWI在鉴定肿瘤床方面是否优越。我们发现，肿瘤组织的透射率（0.12±0.03）低于纤维（0.15±0.04）和脂肪（0.27±0.07）（p <.01）.HDR-DWI在鉴定纤维和肿瘤组织中比橱柜X射线X射线X射线和视觉观察（P <.01）更敏感。此外，HDR-DWI可以鉴定出比目前使用的整个幻灯片成像在12个样品中所使用的纤维化区域更多（12/60）。我们已经确定，与X射线和视觉检查DO相比，HDR-DWI可以提供更多的深度肿瘤床信息，这将有助于防止肿瘤床采样中的诊断错误。
Abstract
Accurate evaluation of residual cancer burden remains challenging because of the lack of appropriate techniques for tumor bed sampling. This study evaluated the application of a white light imaging system to help pathologists differentiate the components and location of tumor bed in specimens.The high dynamic range dual-mode white light imaging (HDR-DWI) system was developed to capture antiglare reflection and multiexposure HDR transmission images. It was tested in 60 specimens of modified radical mastectomy after neoadjuvant therapy. We observed the differential transmittance among tumor tissue, fibrosis tissue, and adipose tissue.The sensitivity and specificity of HDR-DWI were compared with x-ray or visual examination to determine whether HDR-DWI was superior in identifying tumor beds. We found that tumor tissue had lower transmittance (0.12 ± 0.03) than fibers (0.15 ± 0.04) and fats (0.27 ± 0.07) (P < .01).HDR-DWI was more sensitive in identifying fiber and tumor tissues than cabinet x-ray and visual observation (P < .01). In addition, HDR-DWI could identify more fibrosis areas than the currently used whole slide imaging did in 12 samples (12/60). We have determined that HDR-DWI can provide more in-depth tumor bed information than x-ray and visual examination do, which will help prevent diagnostic errors in tumor bed sampling.