癌症的化学动力学治疗因肿瘤微环境中内源性H2O2生成和酸度不足而受限。在此，我们开发了一个生物可降解的治疗学平台（pLMOFePt-TGO），涉及树突状有机硅和FePt合金复合材料，载有他莫昔芬（TAM）和葡萄糖氧化酶（GOx），并被血小板衍生生长因子B（PDGFB）标记的脂质体所包裹。该平台能有效利用化疗、增强化学动力治疗（CDT）和抗血管生成的协同作用。癌细胞中增加的谷胱甘肽（GSH）浓度导致pLMOFePt-TGO的分解，释放出FePt、GOx和TAM。GOx和TAM的协同作用通过有氧葡萄糖消耗和缺氧糖酵解途径分别显著增强了肿瘤微环境的酸度和H2O2水平。 GSH耗竭、酸度增强和H2O2补充的联合作用极大地促进了FePt合金的Fenton催化行为，再加上由GOx和TAM介导的肿瘤饥饿导致的化疗作用，显著提高了此项治疗的抗癌疗效。此外，由于在肿瘤微环境中释放的FePt合金导致了T2缩短，从而显著增强了MRI信号的对比度，从而实现了更加准确的诊断。体外和体内实验的结果表明，pLMOFePt-TGO能够有效地抑制肿瘤生长和血管生成，因此为开发令人满意的肿瘤治疗学提供了一种激动人心的潜在策略。©2023.作者（们）。

Chemodynamic therapy of cancer is limited by insufficient endogenous H2O2 generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and H2O2 level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and H2O2 supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, T2-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics.© 2023. The Author(s).