鼻咽癌在亚洲/太平洋岛屿居民（APIs）中的发病率比其他人种群显著高。通过按人种组和病理学检查年龄特定的发病率模式可以了解疾病病因。我们分析了2000年至2019年国家癌症研究所的监测、流行病学和终末结果（SEER）计划的数据，使用发病率比率和95％置信区间（CI）将非西班牙裔黑人（NH Blacks）、NH APIs和西班牙裔与NH白人的鼻咽癌年龄特定发病率进行比较。NH APIs在所有组织学亚型和几乎所有年龄组中表现出最高的鼻咽癌发病率。人种差异在30-39岁年龄组中最为显著。相对于NH白人，NH APIs分别是分化性非角化性、未分化性非角化性和角化性鳞状细胞肿瘤的发病率的15.24（95％CI：11.69-20.05）、17.26（95％CI：12.56-24.07）和8.91（95％CI：6.79-11.48）倍。这些发现表明NH APIs早期发生鼻咽癌的情况更为常见，这突显了该高危人群早期生命中暴露于关键鼻咽癌风险因素以及基因易感性的独特性。版权所有©2023作者。Elsevier公司保留所有权利。

Incidence of nasopharyngeal cancer is substantially higher in Asian/Pacific Islanders (APIs) than other racial groups. Examining age-specific incidence patterns by racial group and histology could inform disease etiology.We analyzed data from 2000 through 2019 from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program to compare age-specific incidence rates of nasopharyngeal cancer in non-Hispanic (NH) Blacks, NH APIs, and Hispanics to NH Whites using incidence rate ratios with 95% confidence intervals (CIs).NH APIs showed the highest incidence of nasopharyngeal cancer across all histologic subtypes and almost all age groups. The racial differences were most pronounced in the age 30-39 group; relative to NH Whites, NH APIs were 15.24 (95% CI: 11.69-20.05), 17.26 (95% CI: 12.56-24.07), and 8.91 (95% CI: 6.79-11.48) times as likely to have differentiated non-keratinizing, undifferentiated non-keratinizing, and keratinizing squamous cell tumors, respectively.These findings suggest an earlier onset of nasopharyngeal cancer among NH APIs, which highlight unique early life exposure to critical nasopharyngeal cancer risk factors as well as genetic predisposition in this high-risk population.Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.