新陈代谢对乳腺癌免疫微环境的影响。
Effect of metabolism on the immune microenvironment of breast cancer.
发表日期：2023 Feb 20
作者：
Yingming Zhou, Hu Wang, Yi Luo, Biguang Tuo, Xuemei Liu, Taolang Li
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
摘要：
乳腺癌（BC）是一种世界范围内高发的原发性恶性肿瘤，预后不良。尽管有积极介入措施的发展，但由于乳腺癌的死亡率仍然很高。乳腺癌细胞重新编程营养代谢，以适应肿瘤的能量获取和进展。癌细胞代谢变化与免疫细胞和免疫因子的异常功能和作用密切相关，包括趋化因子，细胞因子以及肿瘤微环境（TME）中的其他相关效应分子，导致肿瘤免疫逃逸。免疫细胞和癌细胞之间的复杂交流已被认为是调节癌症进展的关键机制。在本综述中，我们总结了BC进展期间免疫微环境中与代谢相关的最新发现。我们的研究结果显示代谢对免疫微环境的影响，这可能提示通过代谢干预来调节免疫微环境和减轻乳腺癌的新策略。版权所有©2023 Elsevier B.V.出版。
Breast cancer (BC) is a highly prevalent primary malignancy worldwide with poor prognosis. Despite the development of aggressive interventions, mortality due to BC remains high. BC cells reprogram nutrient metabolism to adapt to the energy acquisition and progression of the tumor. The metabolic changes in cancer cells are closely related to the abnormal function and effect of immune cells and immune factors, including chemokines, cytokines, and other related effector molecules in the tumor microenvironment (TME), leading to tumor immune escape, whereby the complex crosstalk between immune cells and cancer cells has been considered the key mechanism regulating cancer progression. In this review, we summarized the latest findings on metabolism-related processes in the immune microenvironment during BC progression. Our findings showing the impact of metabolism on the immune microenvironment may suggest new strategies for regulating the immune microenvironment and attenuating BC through metabolic interventions.Copyright © 2023. Published by Elsevier B.V.