基底细胞癌（BCC）是最为常见的皮肤癌之一。然而，BCC的风险因素，特别是非环境特征，尚未完全确定。因此，我们进行了一项Mendelian随机化（MR）分析，以探索可能的因果风险因素，针对数百万欧洲人进行了研究。我们从公开可用的基因组全关联研究中获得了风险因素的基因变异。最终，本次MR研究分析了43个风险因素，并证明了端粒长度 [比值比（OR）：1.53，95％置信区间（CI）1.35-1.74，p＜0.0001]、出生体重（OR：1.13；95％CI 1.01-1.26，p=0.03）和身高（OR：1.07；95％CI 1.01-1.13，p=0.02）可能与BCC的风险增加有因果关系。然而，并未发现BCC风险和其他风险因素之间的基因易感性。这些发现支持在高风险人群中考虑BCC的预防策略和管理。© 作者（2023） 发布于牛津大学出版社，代表英国皮肤科医师协会的版权所有。保留所有权利。如需许可，请发送电子邮件至：journals.permissions@oup.com。

Basal cell carcinoma (BCC) is one of the most leading skin cancers. However, risk factors of BCC, especially non-environmental features, have not been completely identified. Consequently, we conducted a Mendelian randomization (MR) analysis to explore possible causal risk factors in a cohort of millions of Europeans. We attained genetic variants of risk factors from publicly available genome-wide association studies. Eventually, the present MR study analyzed 43 risk factors, and demonstrated that telomere length [odds ratio (OR): 1.53, 95% confidence interval (CI) 1.35-1.74, p<0.0001], birth weight (OR: 1.13; 95% CI 1.01-1.26, p=0.03), and height (OR: 1.07; 95% CI 1.01-1.13, p=0.02) may casually related to an increased risk of BCC. Nonetheless, no genetic liability between BCC risk and other risk factors was noted. These findings supported prevention strategies and managements for BCC should be considered in high-risk population.© The Author(s) 2023. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.