接受不完全手术和六个周期的化疗的晚期上皮性卵巢癌患者可能从二次手术或巩固性细胞减容手术（CCRS）中受益。本研究的主要目标是评估接受完全CCRS的患者的总体生存率（OS）以及影响生存的因素。次要目标是研究这些患者接受热灌注腹腔化疗（HIPEC）的益处。这是一项回顾性分析，研究了在12个法国中心接受CCRS（n = 118）或不接受CCRS（n = 55）的173名患者。只有完成细胞减容（CC）为0/1的患者以及至少5年的随访量被纳入。除了那些不进行HIPEC治疗的四个中心外，所有患者均进行了系统性HIPEC。腹膜癌指数中位数为6（范围0-33）。闭合式HIPEC在59（34.1％）名患者中执行，开放式HIPEC在56（32.3％）名患者中执行。有64（36.9％）名患者出现3-4级的并发症。中位OS为35.67个月（95％置信区间[CI] 29.8-46.1），并且CCRS + HIPEC的OS显著较长（HIPEC无的OS为31.4个月，有HIPEC的OS为42.5个月，p = 0.022）。在多元分析中，闭式HIPEC（风险比[HR] 0.46，95％CI 0.29-0.73；p <0.001）导致存活时间更长，并且年龄> 65岁（HR 2.17，95％CI 1.14-4.11；p = 0.018）和肠切除（HR 1.98，95％CI 1.27-3.08；p = 0.020）会导致存活时间更短。在多元逻辑回归分析中，闭式HIPEC（比值比0.18；p = 0.001）与5年死亡风险较低相关。CCRS的手术并发症可接受，且总体生存率良好。应在前瞻性、随机的研究中评估HIPEC在CCRS之外的作用，以及比较闭合技术与开放技术。© 2023。外科肿瘤学会。

Patients with advanced epithelial ovarian cancer who undergo incomplete surgery followed by six cycles of chemotherapy could benefit from second-look or consolidation cytoreductive surgery (CCRS). The primary goal of this study was to evaluate the overall survival (OS) in patients undergoing complete CCRS and the factors affecting survival. The secondary goal was to study the benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in these patients.This was a retrospective analysis of 173 patients with CCRS with (n = 118) or without (n = 55) HIPEC treated at 12 French centers. Only patients having a completeness of cytoreduction (CC) 0/1 resection and a minimum of 5 years of follow-up were included. HIPEC was performed systematically for all patients except those treated at the four centers that did not perform HIPEC.The median Peritoneal Cancer Index was 6 (range 0-33). Closed HIPEC was performed in 59 (34.1%) patients and open HIPEC was performed in 56 (32.3%) patients. Grade 3-4 complications occurred in 64 (36.9%) patients. The median OS was 35.67 months (95% confidence interval [CI] 29.8-46.1) and was significantly longer for CCRS + HIPEC (31.4 months without HIPEC and 42.5 months with HIPEC; p = 0.022). On multivariate analysis, closed HIPEC (hazard ratio [HR] 0.46, 95% CI 0.29-0.73; p < 0.001) resulted in a longer OS, and age > 65 years (HR 2.17, 95% CI 1.14-4.11; p = 0.018) and bowel resection (HR 1.98, 95% CI 1.27-3.08; p = 0.020) led to a shorter OS. On multivariate logistic regression analysis, closed HIPEC (odds ratio 0.18; p = 0.001) was associated with a lower risk of dying at 5 years.CCRS was performed with an acceptable morbidity and resulted in good overall survival. The role of HIPEC in addition to CCRS should be evaluated in prospective, randomized studies and the closed technique prospectively compared with the open technique.© 2023. Society of Surgical Oncology.