新冠疫情期间，可怕的COVID-19疾病造成了数百万人的死亡，其最严重的临床表现为急性呼吸窘迫综合征（ARDS）、凝血异常和致死的脓毒症休克。ARDS是细胞因子风暴的后果，病毒性SARS-COV2感染导致细胞因子和花生四烯酸的冰雪崩式释放，从而引起“细胞因子风暴”和“花生四烯酸风暴”。细胞因子风暴是巨噬细胞源性的炎性反应之一，触发的原因是病毒颗粒与肺泡巨噬细胞的ACE2受体结合，主要是由于各种促炎介质如细胞因子（例如白细胞介素（IL）-1、IL-2和肿瘤坏死因子（TNF）-α）过度产生，导致肺水肿、急性呼吸窘迫和多器官衰竭。细胞因子风暴被认为是疾病严重程度的预测因素，并被视为导致COVID-19高死亡率的原因之一。细胞因子风暴的基础是肺泡巨噬细胞在炎症调节反应中从促炎-（M1）到抑炎-（M2）形式的平衡转换，如果肺部存在机会主义性细菌感染，它们会进一步恶化。由于对病毒及其对合并症的影响缺乏足够的了解，临床治疗疾病包括过度使用抗生素以减轻继发性细菌感染，这导致了全球范围内多药耐药（MDR）的不必要发展。需要从各个角度解决抗微生物耐药性（AMR），因为它可能会剥夺未来几代人的基本健康免疫力。特化前炎症调解介质（SPMs）是从必需脂肪酸的立体选择性酶催化转化中产生的，可以作为免疫解决物控制急性炎症反应。SPMs促进损伤组织和细胞残骸的清除，清除病原体，并增加抗炎脂质介质的浓度。SPMs，例如脂氧素、保护素和解决素已被证实对细胞因子风暴具有抑制作用。实验证据表明，SPMS降低了抗生素需求。因此，在本次评论中，讨论了SPMs在增强巨噬细胞极化、触发免疫功能、加速炎症解决、减轻细胞因子风暴和降低抗生素需求方面的潜在作用，从而减轻AMR负担。版权所有 © 2023 Kumar，Yasmeen，Chaudhary，Alawam，Al-Zharani，Suliman Basher，Harikrishnan，Goud，Pandey，Lakhawat和Sharma。

The most severe clinical manifestations of the horrifying COVID-19 disease, that claimed millions of lives during the pandemic time, were Acute respiratory distress syndrome (ARDS), Coagulopathies, septic shock leading eventually to death. ARDS was a consequence of Cytokine storm. The viral SARS-COV2infection lead to avalanche of cytokines and eicosanoids causing "cytokine storm" and "eicosanoid storm." Cytokine storm is one of the macrophage-derived inflammatory responses triggered by binding of virus particles to ACE2 receptors of alveolar macrophages, arise mainly due to over production of various pro-inflammatory mediators like cytokines, e.g., interleukin (IL)-1, IL-2, and tumor necrosis factor (TNF)- α, causing pulmonary edema, acute respiratory distress, and multi-organ failure. Cytokine storm was regarded as the predictor of severity of the disease and was deemed one of the causes of the high mortality rates due to the COVID-19. The basis of cytokine storm is imbalanced switching between an inflammation increasing - pro-inflammatory (M1) and an inflammation regulating-anti-inflammatory (M2) forms of alveolar macrophages which further deteriorates if opportunistic secondary bacterial infections prevail in the lungs. Lack of sufficient knowledge regarding the virus and its influence on co-morbidities, clinical treatment of the diseases included exorbitant use of antibiotics to mitigate secondary bacterial infections, which led to the unwarranted development of multidrug resistance (MDR) among the population across the globe. Antimicrobial resistance (AMR) needs to be addressed from various perspectives as it may deprive future generations of the basic health immunity. Specialized pro-resolving mediators (SPMs) are generated from the stereoselective enzymatic conversions of essential fatty acids that serve as immune resolvents in controlling acute inflammatory responses. SPMs facilitate the clearance of injured tissue and cell debris, the removal of pathogens, and augment the concentration of anti-inflammatory lipid mediators. The SPMs, e.g., lipoxins, protectins, and resolvins have been implicated in exerting inhibitory influence on with cytokine storm. Experimental evidence suggests that SPMS lower antibiotic requirement. Therefore, in this review potential roles of SPMs in enhancing macrophage polarization, triggering immunological functions, hastening inflammation resolution, subsiding cytokine storm and decreasing antibiotic requirement that can reduce AMR load are discussed.Copyright © 2023 Kumar, Yasmeen, Chaudhary, Alawam, Al-Zharani, Suliman Basher, Harikrishnan, Goud, Pandey, Lakhawat and Sharma.