Vasa，一个调节纺锤体局部mRNA翻译的蛋白。
Vasa, a regulator of localized mRNA translation on the spindle.
发表日期：2023 Feb 24
作者：
Paola Alejandra Sundaram Buitrago, Kavya Rao, Mamiko Yajima
来源：
BIOESSAYS
摘要：
本文将就定位mRNA翻译这一生物过程提出看法，这一过程允许mRNA在现场翻译，有望为细胞内蛋白质调节提供时空精细控制。我们最近报道了RNA解旋酶Vasa在海胆胚胎发育期间在纺锤体上调节此过程的潜在因素，然而Vasa在此过程中的详细作用和功能机制仍大多未知。本文将首先总结Vasa研究领域的先前知识和我们的最新发现，并进一步讨论Vasa如何在定位mRNA翻译中发挥功能，促进快速胚胎成长和癌细胞调节的高效蛋白质调节。 © 2023 Wiley Periodicals LLC.
Localized mRNA translation is a biological process that allows mRNA to be translated on-site, which is proposed to provide fine control in protein regulation, both spatially and temporally within a cell. We recently reported that Vasa, an RNA-helicase, is a promising factor that appears to regulate this process on the spindle during the embryonic development of the sea urchin, yet the detailed roles and functional mechanisms of Vasa in this process are still largely unknown. In this review article, to elucidate these remaining questions, we first summarize the prior knowledge and our recent findings in the area of Vasa research and further discuss how Vasa may function in localized mRNA translation, contributing to efficient protein regulation during rapid embryogenesis and cancer cell regulation.© 2023 Wiley Periodicals LLC.