动态染色质结构作为转录程序在癌症和细胞发育等关键过程中的调节器，但尚未建立起一个统一的框架来描述染色质结构演变。在这里，我们对Hi-C数据集进行图推理，得出了染色质接触网络。我们通过图形统计发现，与相应的正常对照组相比，结直肠癌（CRC）和T细胞急性淋巴细胞白血病（T-ALL）的染色质信息传输效率显著降低。利用Poincaré圆盘中的网络嵌入，发现CRC和T-ALL患者的染色质层次深度明显降低，与其正常对照组相比。在早期胚胎发育中观察到了染色质结构的反向趋势变化。我们发现染色质接触网络中存在组织特异性的层次顺序。我们的发现揭示了染色质组织的自上而下的层次结构，这在癌症中明显衰减。©2023 Wang等人；由Cold Spring Harbor实验室出版。

Dynamic chromatin structure acts as the regulator of transcription program in crucial processes including cancer and cell development, but a unified framework for characterizing chromatin structural evolution remains to be established. Here, we performed graph inferences on Hi-C data sets and derived the chromatin contact networks. We discovered significant decreases in information transmission efficiencies in chromatin of colorectal cancer (CRC) and T-cell acute lymphoblastic leukemia (T-ALL) compared to corresponding normal controls through graph statistics. Using network embedding in the Poincaré disk, the hierarchy depths of chromatin from CRC and T-ALL patients were found to be significantly shallower compared to their normal controls. A reverse trend of change in chromatin structure was observed during early embryo development. We found tissue-specific conservation of hierarchy order in chromatin contact networks. Our findings reveal the top-down hierarchy of chromatin organization, which is significantly attenuated in cancer.© 2023 Wang et al.; Published by Cold Spring Harbor Laboratory Press.