我们研究了周末效应对患癌症接受择期食管切除手术患者的生存结果的影响。这是对全国性卫生行政数据集的回顾性分析，包括2008年至2015年间在台湾医院接受择期食管切除手术的所有患者（n = 3235）。患者根据手术日进行分类（工作日组：从周一到周五开始进行手术的手术程序，n = 3148；周末组：从周六或周日开始进行手术的手术程序，n = 87）。使用倾向分数的反向治疗加权（IPTW）来纠正由于基线差异而导致的选择偏倚。经过IPTW后，周末接受食管切除手术的患者的90天死亡率比工作日手术的患者高（分别为10.5％和5.5％，P <0.001）。在控制潜在混杂因素后，周末手术被确定为2年总生存的独立不良预测因子[风险比（HR）= 1.38，P <0.001]。重要的是，较差的周末结果在某些亚组中尤为明显，包括年龄> 60岁（HR = 1.61，P <0.001）的患者，以及负担较高的合并症（HR = 1.32，P <0.001）、晚期肿瘤分期（HR = 1.50，P <0.001）、鳞状细胞癌的组织学诊断（HR = 1.20，P <0.001），以及接受微创食管切除术的患者（HR = 1.26，P <0.001）。在周末进行的癌症择期食管切除术对短期和长期生存结果产生了负面影响。©2023年。外科肿瘤学会。

We examined the impact of the weekend effect on the survival outcomes of patients undergoing elective esophagectomy for cancer.This was a retrospective analysis of a nationwide, health administrative dataset that included all patients (n = 3235) who had undergone elective esophagectomy for cancer in Taiwanese hospitals between 2008 and 2015. Patients were categorized according to the day of surgery (weekday group: surgical procedures starting Monday through Friday, n = 3148; weekend group: surgical procedures starting on Saturday or Sunday, n = 87). Inverse probability of treatment weighting (IPTW) using the propensity score was used to account for selection bias due to baseline differences.After IPTW, patients undergoing esophagectomy on weekends had a higher 90-days mortality rate compared with those undergoing surgery on a weekday (10.5% vs. 5.5%, respectively, P < 0.001). After controlling for potential confounders, weekend surgery was identified as an independent adverse predictor of 2-years, overall survival [hazard ratio (HR) = 1.38, P < 0.001]. Importantly, inferior weekend outcomes were especially evident in certain subgroups, including patients aged > 60 years (HR = 1.61, P < 0.001), as well as those with a high burden of comorbidities (HR = 1.32, P < 0.001), advanced tumor stage (HR = 1.50, P < 0.001), histological diagnosis of squamous cell carcinoma (HR = 1.20, P < 0.001), and treated with minimally invasive esophagectomy (HR = 1.26, P < 0.001).Elective esophagectomy for cancer during weekends has an adverse impact on short- and long-term survival.© 2023. Society of Surgical Oncology.