化疗是癌症治疗中最重要的一种方法。然而，化疗抵抗是癌症治疗中的一大挑战。由于化疗抵抗，药物的功效变得不那么有效或者完全无效。近年来，发现长链非编码RNA转移相关肺腺癌转录本1（MALAT1）与化疗抵抗的发展有关，表明MALAT1可能是克服化疗抵抗的重要靶点。在本文中，我们介绍了与MALAT1相关的化疗抵抗的主要机制，这可能为癌症治疗提供新的方法。©2023作者。

Chemotherapy is one of the most important treatments for cancer therapy. However, chemotherapy resistance is a big challenge in cancer treatment. Due to chemotherapy resistance, drugs become less effective or no longer effective at all. In recent years, long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been found to be associated with the development of chemotherapy resistance, suggesting that MALAT1 may be an important target to overcome chemotherapy resistance. In this review, we introduced the main mechanisms of chemotherapy resistance associated with MALAT1, which may provide new approaches for cancer treatment.© 2023. The Author(s).