血脑屏障（BBB）是最具选择性的内皮屏障之一，保护大脑并在神经微环境中维持稳态。该屏障限制分子进入大脑，除了气体或极小的疏水分子。因此，BBB阻碍分子量较大的药物通过治疗脑癌。已经使用多种方法规避BBB来将药物输送到大脑，但是它们有药物多样性和输送效率低等局限性。为了克服这个挑战，基于微泡（MBs）的药物输送系统近年来备受关注。MBs广泛用作对比剂，最近也被研究成为输送药物、蛋白质和基因复合物的载体。MBs大小为1-10微米，由气体核心和有机壳组成，响应超声波而导致物理变化，如气泡膨胀、收缩、振动和破裂。MBs的物理变化和所产生的能量导致BBB的生物学变化，促使药物穿透其，从而增强治疗效果。特别是，本文论述了制备基于MBs的输送平台及其在脑癌治疗中用超声的最新策略。

The blood-brain barrier (BBB) is one of the most selective endothelial barriers that protect the brain and maintains homeostasis in neural microenvironments. This barrier restricts the passage of molecules into the brain, except for gaseous or extremely small hydrophobic molecules. Thus, the BBB hinders the delivery of drugs with large molecular weights for the treatment of brain cancers. Various methods have been used to deliver drugs to the brain by circumventing the BBB; however, they have limitations such as drug diversity and low delivery efficiency. To overcome this challenge, microbubbles (MBs)-based drug delivery systems have garnered a lot of interest in recent years. MBs are widely used as contrast agents and are recently being researched as a vehicle for delivering drugs, proteins, and gene complexes. The MBs are 1-10 μm in size and consist of a gas core and an organic shell, which cause physical changes, such as bubble expansion, contraction, vibration, and collapse, in response to ultrasound. The physical changes in the MBs and the resulting energy lead to biological changes in the BBB and cause the drug to penetrate it, thus enhancing the therapeutic effect. Particularly, this review describes a state-of-the-art strategy for fabricating MB-based delivery platforms and their use with ultrasound in brain cancer therapy.