由于肝癌发病率的不断上升以及对目前化疗药物毒性的担忧，寻找治疗这种恶性肿瘤的替代方法已经升级。和化疗相比，黄酮类化合物（flavonoid）槲皮素（quercetin）对正常细胞相对较少有害，并被认为是一种优秀的自由基清除剂。多个先前的研究已经证明它对癌细胞的凋亡细胞死亡产生了影响。槲皮素存在于许多水果、蔬菜和草药中。槲皮素通过上调Bax、caspase-3和p21，同时下调Akt、PLK-1、cyclin-B1、cyclin-A、CDC-2、CDK-2和Bcl-2，以靶向凋亡。此外，据报道它可以增加肝癌细胞中STAT3蛋白的降解，同时减少STAT3的激活。槲皮素在化学预防方面具有潜在的未来，基于其抗癌效果的大量研究。本文综述了槲皮素在肝癌中的作用机理、纳米递送策略和其他潜在的细胞效应。

Due to rising incidence rates of liver cancer and worries about the toxicity of current chemotherapeutic medicines, the hunt for further alternative methods to treat this malignancy has escalated. Compared to chemotherapy, quercetin, a flavonoid, is relatively less harmful to normal cells and is regarded as an excellent free-radical scavenger. Apoptotic cell death of cancer cells caused by quercetin has been demonstrated by many prior studies. It is present in many fruits, vegetables, and herbs. Quercetin targets apoptosis, by upregulating Bax, caspase-3, and p21 while downregulating Akt, PLK-1, cyclin-B1, cyclin-A, CDC-2, CDK-2, and Bcl-2. Additionally, it has been reported to increase STAT3 protein degradation in liver cancer cells while decreasing STAT3 activation. Quercetin has a potential future in chemoprevention, based on substantial research on its anticancer effects. The current review discusses quercetin's mechanisms of action, nanodelivery strategies, and other potential cellular effects in liver cancer.